Atofina

Centre National De La Recherche Scientifique

Université´ D'aix-marseille

Arkema France

Université De Provence

Other

Commissariat a L'energie Atomique

Eth Zurich

Universite Claude Bernard – Lyon1

The Medical College of Wisconsin, Inc.

Bruker Biospin Gmbh

Ecole Normale Superieure De Lyon

Massachusetts Institute of Technology

Bruker France S.a.s.

Paul Tordo

Olivier Ouari

Francois Le Moigne

Olivier Guerret

Jean-Luc Couturier

Jean-Pierre Bernard Finet

Hakim Karoui

Thierry Senninger

Didier Gigmes

Denis Bertin

Micael J Hardy

Yoh Matsuki

Robert G Griffin

Melanie Rosay

Elisabetta Damiani

Lucedio Greci

Sylvain Marque

Eric Minaux

Michael Buback

Thorsten Maly

Fabien Aussenac

Pierluigi Stipa

Patricia Carloni

Giampaolo Tommasi

Gilles Casano

Jean-Philippe Gillet

Pascal Nicol

Balaraman Kalyanaraman

Christophe Coperet

Nelly Kernevez

Yves Gnanou

Sandra Grimaldi

Marcos Lopez

Christophe Le Mercier

Muriel Plechot

Jean-Francois Lutz

Sylvia Pietri

Marcel Culcasi

Liliane Secourgeon

Oliver Ouari

Florence Chauvin

Pierre-Emmanuel Dufils

Florence Nathalie Laurence Chalier

Pierre-emmanuel Dufils

Claire Sauvee

Anne Lesage

Aaron Rossini

Christiane Henriet-Bernard

Fran&ccedil;ois Lemoigne

Lyndon Emsley

Yves Berchadsky

Anne Mercier

Alexandre Zagdoun

Viviane Cerri

Beatrice Tuccio

Abdelhamid Zeghdaoui

Claudine Marie Barbe Frejaville

Neil Hogg

Mélanie Rosay

Christophe COPÉRET

François Le Moigne

The present invention relates to a dinitroxide biradical compound of general formula (I): In formula (I), A is a carbon, an ammonium, or a phosphonium; each of A1 to A6 is a single bond, O, N, N(O), S, S(O), SO, C(O), or a (C1-C4) alkyl chain; and Z1 and Z2 are selected from R1 and R2 in combination, so that there is always at least one R2 group that is substituted with R3 group. In Z1 and Z2, R1 is an H, an aryl, or a heteroaryl; R2 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, or a heteroaryl; and R3 is an alkyl chain, an alkenyl chain, an alkynyl chain, a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl, an ether, an ester, or an azide. When Z1 and Z2 are combined together with the same carbon atom of the nitroxide ring to which they are bonded, they form a spirocycloalkyl or a spiroheterocycloalkyl, the spirocycloalkyl or the spiroheterocycloalkyl being substituted with R3.

Rigid dinitroxide biradical compounds used as improved polarizing agents for dynamic nuclear polarization techniques

The invention relates to compounds of general formula (I) wherein X is C&#x2550;O or SO, M is NRor O, and Qand Qare nitroxide-containing radicals, and their use as a Dynamic Nuclear Polarization (DNP) agent for polarizing an NMR-active spin of a nucleus of an analyte in Nuclear Magnetic Resonance (NMR) spectroscopy. 

Highly efficient polarizing agents for dynamic nuclear polarization

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP)

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals in biological samples.

Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof

A subject-matter of the invention is alkoxyamines resulting from &#x3b2;-phosphorated nitroxides corresponding to the formula: in which R represents an alkyl radical having a number of carbon atoms ranging from 1 to 3, Rrepresents a hydrogen atom or a residue: in which Rrepresents an alkyl radical having a number of carbon atoms ranging from 1 to 20, and Rrepresents a hydrogen atom, an alkyl radical having a number of carbon atoms ranging from 1 to 8, a phenyl radical, an alkali metal, such as Li, Na or K, HN, BuNor BuHN, exhibiting a kinetic dissociation constant kd, measured at 120&#xb0; C. by EPR, of greater than 0.05 s. These compounds can be used as initiators for the (co)polymerizations of at least one monomer which can be polymerized by the radical route.

Alkoxyamines originating from &#x3b2;-phoshorated nitroxides and use thereof in radical polymerisation

The present invention involves new nitrons carrying a positive charge, useful in trapping of free radicals and especially the superoxide radical, of general formula: 

Nitrons carrying a positive charge and usable in trapping free radicals, especially the superoxide radical

The invention relates to the use of alkoxyamines of formula (I): for the preparation of polymerized or non-polymerized mono- or polyalkoxyamines of formula (II): 

Alkoxyamines derived from beta-phosphorylated nitroxides, and use thereof for preparing polymerized or non-polymerized mono- or polyalkoxyamines

Process for the controlled radical polymerization or copolymerization of ethylene under high pressure in the presence of initiating free radicals and of controlling indoline nitroxide radicals

The invention concerns a method for preparing &bgr;-phosphorous nitroxide radicals which comprises preparing in a first step an aminophosphonate by reacting a carbonyl compound, a primary amine and a phosphorous compound, then in a second step in oxidizing said aminophosphonate using on-halogenated organic peracids in a two-phase organic water/solvent medium with a buffered aqueous phase with a pH ranging between 5 and 12.

Method for preparing &bgr;-phosphorous nitroxide radicals

The invention concerns alkoxyamines derived from &bgr;-phosphorous nitroxides corresponding to formula (I). Said compounds can be used as (co)polymerization initiators of at least a monomer polymerizable by radical polymerization.

Alkoxyamines derived from &bgr;-phosphorous nitroxides

The invention relates to a process for the polymerization or copolymerization of at least one monomer which is polymerizable by the radical route in the presence of a stable free radical from the nitroxide family. The stable free radical is &bgr;-substituted and provides excellent control of polydispersity while ensuring a better rate of polymerization or copolymerization, if they are compared with the stable free radicals used in the prior art.

Polymerization in the presence of a &bgr;-substituted nitroxide radical

Phosphorylated nitrone derivatives, method for preparing same, and

Nitrones which are usable for the scavenging of free radicals

Growing community of inventors

Marseilles, France

Paul Tordo