Affinergy Inc.

Other

Becton Dickinson and Company Limited

E.i. Dupont De Nemours and Company

Vmac, LLC

Exhaust Track, Inc.

Depuy Synthes Products, Inc.

Albert Einstein College of Medicine

Synthes Usa, LLC

Synthes Gmbh

Paul Theodore Hamilton

Wayne F Beyer

Robin Hyde-DeRuyscher

Ray Edward Benson

Michael C Little

Shrikumar Ambujakshan Nair

Robert E Pearson

Julie A Dickson

Yuchen Chen

Hanne Gron

Martyn Kerry Darby

J Scott Perry

Wallace C Turbeville

R Edward Benson

Daniel James Kenan

Isaac Gilliam Sanford

Edward A Pfeiffer, Jr

Hong Peng Wang

John P O'Brien

Stephen R Fahnestock

Jonathan Allen Hodges

Michelle Steffen Jansen

Mark W Grinstaff

Elliott A Gruskin

Barry R Bloom

Dale J Christensen

Ganesan Sathya

Doug Buechter

John Chan

Dalia Isolda Juzumiene

Paul Riska

Stewart Jurgensen

Benjamin Marcus Buehrer

Amy Katherine Solan

Mohmed Anwer

Guy Orgambide

Isaac G Sanford

Wayne Fl Beyer

Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

Methods and compositions for soft tissue repair

The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces

A paired basis swap risk and credit mitigation system and collateral minimization system. In swaps used to hedge forward contracts a system authority interposes itself and forms paired basis swaps with each of the paired swap participants and itself together with a Swaption to allow it to maintain a level book in the event of a default by any counterparty. In the event of a default the system authority has the ability to either terminate a swap and pay the non-defaulting counterparty an agreed upon termination payment, terminate the non-defaulting counterparty's swap and exercise the swaption to substitute a correlated swap with appropriate correlated termination payment; or substitute a new counterparty with an identical swap as the paired swap participant. Paired basis swap control through delivery can be enabled to continue the risk and credit mitigation benefits of the system.

Paired basis swap risk and credit mitigation system and collateral minimization system

Peptides have been identified that bind with high affinity to hair. Peptide-based hair reagents formed by coupling a hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of at least one hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively.

Hair binding peptides and peptide-based hair reagents for personal care

Peptides have been identified that bind with high affinity to dyed hair. Peptide-based hair reagents formed by coupling a dyed-hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of a dyed-hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based hair reagents or the dyed-hair-binding peptides may also be used as a protective sealant to improve color retention of dyed hair.

Dyed-hair-binding peptides and peptide-based hair reagents for personal care

The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.

Methods and compositions for delivery of growth factor to fibrous connective tissue

The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material ('implant module') and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect ('analyte module'). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.

IFBM'S to promote the specific attachment of target analytes to the surface of orthopedic implants

IFBM's to promote the specific attachment of target analytes to the surface of orthopedic implants

The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.

Peptide compositions for coating metal medical devices with vancomycin

An agency payment system for transactions covered by a virtual market control entity between participants. The system determines all payments required to be made by each virtual market control entity participant on a given day. It nets all of each of the participant's required payments to be made with the payments received by the virtual market control entity on the previous day due to each participant to obtain a net cash movement, either from the virtual market control entity to the participant's account or from the participant's account to the virtual market control entity. It transfers between the participant's account and the virtual market control entity's account and each participant's account the net cash movements to the virtual market control entity's account. It then transfers between the virtual market control entity's account and each participant's account the net cash movements to the participant's account.

Agency payment system

Growing community of inventors

Cary, NC, United States of America

Paul Theodore Hamilton