Biotechnology Research Development Corporation

United States of America, As Represented by the Secretary of Agriculture

The Nutrasweet Company

Pcbu Services, Inc.

Zuchem, Inc.

The United States of America, As Represented by Sec. of Agriculture

Paul Taylor

Nathan Wymer

Badal C Saha

Ian G Fotheringham

Francis Michael Racine

David C Demirjian

David J Ager

Roberta K Yoshida

Weiguo Liu

Yoshikiyo Sakaibara

Yoshikiyo Sakakibara

Scott Laneman

The invention provides methods and compositions for the production of L-ribitol and other rare sugars using a mannitol-1-dehydrogenase.

Production of L-ribose and other rare sugars

The invention provides biosynthetic routes to xylitol production that do not require pure-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.

Methods for production of xylitol in microorganisms

Recombinant microorganisms are useful for producing xylitol by fermentation of arabinose. The recombinant microorganisms are produced by transformation of host microorganisms with heterologous polynucleotide sequences coding for each of L-xylulose reductase, D-tagatose 3-epimerase, and L-arabinose isomerase, which transformants express the heterologous polynucleotides at a sufficient functional level to be effective to produce xylitol from arabinose. Production of xylitol is effected by contacting these recombinant microorganisms with a substrate comprising arabinose under conditions effective to produce xylitol from arabinose.

Method for microbial production of xylitol from arabinose

A process for stereoselectively inverting a chiral center of a chemical compound is disclosed. The process first consists of forming a mixture of the chemical comopund, an enzymatic system, and a metal catalyst. Next, the process stereoselectively dehydrogenates a group attached to the chiral center with the enzymatic system in the presence of an oxidant to produce a dehydrogenated group, Lastly, the process hydrogenates the dehydrogenated group with the metal catalyst in the presence of a hydrogen source to stereoselectively invert the chiral center of the chemical compound.

Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst

The present invention provides materials and methods for production of D-phenylalanine by recombinant expression in a microorganisms of a D-aminotransferase gene and optionally a dadX gene in optional combination with eliminating or reducing expression of L-transaminase genes.

Materials and methods for the production of D-phenylalanine

Growing community of inventors

Arlington Heights, IL, United States of America

Paul Taylor