The United States of America, As Represented by the Secretary, Department of Health and Human Services

Paul T Wingfield

Alasdair C Steven

Stuart A Aaronson

Jeffrey S Rubin

Donald P Bottaro

Andrew M L Chan

Lindsay W Black

Zhaojun Ren

Stephen J Stahl

Norman R Watts

Vittoria Cioce

Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Hepatitis B Virus infection in mammals, and to methods of using those compositions of matter for the same.

Antibodies and methods for the diagnosis and treatment of hepatitis b virus infection

The present invention relates to a novel truncated form of heptocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.

Truncated hepatocyte growth factor variant protein HGF/NK2

Disclosed is a phage display system in which the molecules to be displayed (i.e., molecules of interest) are bound to dispensable capsid polypeptides such as SOC (small outer capsid) and HOC (highly antigenic outer capsid) polypeptides that are, in turn, bound to a surface lattice protein, such as those on the surface of a virion or polyhead. Also disclosed are methods of displaying a molecule of interest, methods of immunizing a patient by administering a displayed antigen, and methods of treating a patient who has a disorder associated with aberrent expression or activity of a biological molecule. In the latter instance, the method includes administering a displayed polypeptide, such as an immunoglobulin molecule or an enzyme, that is capable of specifically interacting with the aberrent biological molecule.

Phage display of intact domains at high copy number

Growing community of inventors

Bethesda, MD, United States of America

Paul T Wingfield