Sepracor, Inc.

Sunovion Pharmaceuticals Inc.

Paul T Grover

Chris Hugh Senanayake

Q Kevin Fang

Mark G Currie

Qun Kevin Fang

Steve Jones

Thomas P Jerussi

Roger P Bakale

Donald L Heefner

Richard F Rossi

Stephen Alan Wald

Kerry Leigh Spear

Chrisantha Hugh Senanayake

Seth C Hopkins

Una Campbell

Frank Wu

Milan Chytil

Kevin Q Fang

Compositions containing &#x3b2;adrenergic agonists in combination with carbonates and carbamates of the formula. and in combination with related steroid carbonates and carbamates are disclosed. The compositions are useful for treating bronchospasm, for inducing bronchodilation and for treating rhinitis, asthma, and chronic obstructive pulmonary disease (COPD) and inflammatory diseases, particularly by inhalation.

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Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed. Many of the compounds disclosed herein may be represented by the following generic formula: 

Imidazo[1,2-a]pyridine compounds

Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists

Imidazo[1,2-a]pyridines of the formulae I and II: are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A representative compound of the invention is: 

Imidazo[1,2-A]pyridine anxiolytics

Imidazo[1,2-A] pyridine anxiolytics

Compositions containing &#x3b2;adrenergic agonists in combination with carbonates and carbonates of the formula and in combination with related steroid carbonates and carbonates are disclosed. The compositions are useful for treating bronchospasm, for inducing bronchodilator and for treating rhinitis, asthma, and chronic obstructive pulmonary disease (COPD) and inflammatory diseases, particularly by inhalation.

Compositions containing &#x3b2;adrenergic agonists in combination with carbonates and carbamates of the formula and in combination with related steroid carbonates and carbamates are disclosed. The compositions are useful for treating bronchospasm, for inducing bronchodilation and for treating rhinitis, asthma, and chronic obstructive pulmonary disease (COPD) and inflammatory diseases, particularly by inhalation.

Imidazo[1,2-a] pyridine anxiolytics

Carbonates and carbamates of the formulaand related steroid carbonates and carbamates are disclosed. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.

Carbonate and carbamate modified forms of glucocorticoids

Tramadol analogs and uses thereof

A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or aldehyde to provide a 5-(1-hydroxyalkyl)-5-phenyl-1,3-dioxolan-4-one, which is dehydrated to a 5-(1-alkenyl)-5-phenyl-1,3-dioxolan-4-one. The 5-(1-alkenyl)-5-phenyl-1,3-dioxolan-4-one may be hydrolyzed and reduced to an &agr;-alkylphenylglycolic acid or the hydrolysis and reduction steps may be reversed. The process enables the production of single enantiomers of cyclohexylphenylglycolic acid (CHPGA). An analogous process for racemic CHPGA is disclosed employing racemic mandelic acid and acetone. Novel intermediates in the process are also disclosed.

Stereoselective process for alkyl phenylglycolic acids

Methods are disclosed which utilize metabolites of bupropion for treating sexual dysfunction.

Bupropion metabolites and methods of use

Processes for preparing a single enantiomer of an .alpha.,.alpha.-disubstituted-.alpha.-hydroxy acetic acid, especially cyclohexylphenylglycolic acid (CHPGA), is disclosed. The processes employ cyclic 1,2-aminoalcohols as chiral auxiliaries by forming diastereomeric esters of aminoalcohols or diastereomeric amides of oxazolidines. ##STR1## Intermediates useful in the process are also disclosed.

Growing community of inventors

Franklin, MA, United States of America

Paul T Grover