Orthopeutics, L.p.

Antigenics, Inc.

Paul Slusarewicz

Thomas P Hedman

Sunil Mehta

Jessica Baker Flechtner

Kenya Prince-Cohane

Sofija Andjelic

Brian H Barber

Improved methods and compositions for the treatment of native tissues with crosslinkers are provided. The methods and compositions will find particular use in increasing resistance to tearing, fissuring, rupturing, and/or delamination.

Formulations for nonsurgical exogenous crosslink therapy

A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in the tissue.

Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity

Hybrid antigens comprising an antigenic domain and improved heat shock protein binding domains are described which are useful for the induction of an immune response to the antigenic domain and thus can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.

Heat shock protein-based vaccines and immunotherapies

Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when administered alone or in a complex with at least one heat shock protein. The hybrid antigens and complexes can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.

Growing community of inventors

San Antonio, TX, United States of America

Paul Slusarewicz