Koninklijke Philips Corporation N.V.

Paul Sheeran

Charles Tremblay-Darveau

Thanasis Loupas

Jeffry E Powers

William Tao Shi

Shiying Wang

Hua Xie

Claudia Errico

Vijay Thakur Shamdasani

Liang Zhang

Allison Arden Daniels

Systems and methods for multi-level vascular imaging for construction and display of vasculature from large to small vessels and micro-vessels using a combination of varying resolution contrast enhanced ultrasound flow imaging modalities are disclosed. While one or more resolution flow imaging modes may be employed for imaging large to small vessels of a vascular tree within a large region of interest, a high resolution mode, such as super resolution imaging, constructed for delineation of the microvascular morphology and directional microcirculation is provided within one or more small ROIs placed in selected locations within the larger ROI.

Systems and methods for vascular imaging

Systems and methods for time-varying two-dimensional (2D) color maps for visualizing images or sequences of images are disclosed. The 2D color map may include brightness values of a hue corresponding to different intensities that changes over time. In some 2D color maps, the hue used for the intensity scale may change over time while the brightness of a pixel may not. In some 2D color maps, both the hue and the brightness may change relative to intensity over time.

Systems and methods for color mappings of contrast images

Systems and methods for preprocessing three dimensional (3D) data prior to generating inverted renders are disclosed herein. The preprocessing may include segmenting the 3D data to remove portions of the data associated with noise such that those portions do not appear in the generated render. The segmentation may include applying a mask to the 3D data. The mask may be generated by sorting data points in the 3D data set into a first set or a second set. In some examples, the 3D data may be filtered prior to generating the mask. In some examples, the mask may be adjusted based on feature recognition. The preprocessing may allow the visualization of hypoechoic regions of interest in a volume.

Methods and systems for segmentation and rendering of inverted data

A particular sequence of ultrasound transmissions and corresponding echo receptions enables the production of Amplitude Modulated (AM) and Amplitude Modulated Phase Inverted (AMPI) signals that are temporally balanced. Temporal balancing significantly reduces tissue artifacts caused by movement of tissue during acquisition of the ultrasound echoes. Additionally, in combining the selected echo signals to produce the AM5 and AMPI signals, and optionally a Phase Inverted (PI) signal, each of the echo signals is equally weighted to facilitate an amplitude balance that avoids different echoes affecting the produced AM, AMPI, and PI signals differently.

Temporally balanced multi-mode master imaging sequence for ultrasonic contrast imaging

The present disclosure describes ultrasound systems configured to perform microbubble-based contrast imaging with enhanced sensitivity. The systems can enhance echo signals derived from microbubbles while suppressing echo signals derived from tissue by detecting phase shifts exhibited by microbubbles in resonance. To detect the phase shifts, and thereby distinguish between microbubble-based signals and tissue-based signals, the systems can transmit a series of ultrasound pulses into a target region in accordance with a predefined sequence. The sequence can include an initiation pulse configured to stimulate microbubbles into nonlinear oscillation, a detection pulse configured to detect the nonlinear oscillation, and a summation pulse formed by transmitting an initiation pulse and detection pulse with a small time delay therebetween. A signal processor included in the system can determine phase shifts exhibited by the signals generated in response to the series of pulses and mask non-microbubble-based signals based on the magnitude of the detected phase shifts.

Microbubble-based contrast imaging using phase shift systems and methods

In some examples, color Doppler data may be separated into luminance data and chrominance data. The luminance data may be modified without modifying the chrominance data. In some examples, the luminance data may be adjusted based, at least in part, on power Doppler data. The adjusted luminance data may be recombined with the chrominance data to provide augmented color Doppler data. In some examples, the power Doppler data may be enhanced by filtering, for example, by applying a Frangi vesselness filter, prior to being used to adjust the luminance data of the color Doppler data.

Systems and methods for vascular rendering

Aspects of the present disclosure provide ultrasound systems and devices that provide for reduction of reverberation artifacts in ultrasound images by automatically changing imaging settings such as PRI or transmit/receive configuration based on detected amounts of reverberation in ultrasound images. In an exemplary embodiment, an apparatus includes a processor circuit in communication with an ultrasound probe. The processor circuit obtains a plurality of ultrasound images obtained using a plurality of different PRIs and/or pulse sequences, calculates an amount of reverberation artifacts in each of the plurality of ultrasound images, selects a pulse repetition interval and/or pulse sequence based on the amounts of reverberation artifacts in each of the plurality of ultrasound images, and controls the ultrasound transducer to obtain a reduced-reverberation ultrasound image using the selected pulse repetition interval or pulse sequence. The reduced-reverberation ultrasound image is then output to a display.

Reduction of reverberation artifacts in ultrasound images and associated devices, systems, and methods

An ultrasound system produces persisted images in response to both persistence coefficients and noise bias coefficients. The persistence coefficients control the degree of persistence, which reduces noise variance by persistence processing. The noise bias coefficients are produced in correspondence with the likelihood that an image pixel is noise, and operate to reduce the noise floor of the persisted images. A single user control enables a user to control both the noise variance and the noise level of images in tandem or, alternatively, dedicated controls can become available to adjust noise variance and noise level separately.

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Woodinville, WA, United States of America

Paul Sheeran