Syntex (u.s.a.) Inc.

Novartis Ag

Roche Palo Alto LLC

Other

Sandoz Gmbh

Iowa State University Research Foundation, Inc.

F. Hoffmann-la Roche Ag

Paul Shartzer Dietrich

Ulrich Andreas Gubler

Lakshmi Sangameswaran

Linda Marie Fish

Stephen Gregory Delgado

Ralph M Sinibaldi

Joseph Gerrard McGivern

Bruce Koch

Heather Guthrie

Lynn E Murry

Bruce Marvin Held

Eve Syrkin Wurtele

Irvin J Mettler

Ronald Herman

Johannes Jacobus Gielen

Martinus Quirinus Van Grinsven

Johannes Maria De Haas

Roeland Van Driel

Ronald Charles Herman

Sharon C Alfinito

James T Colbert

Joseph Gerard McGivern

A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.

Stable cell lines expressing hERG

The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.

T-type calcium channel variants; compositions thereof; and uses

DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.

Cloned tetrodotoxin-sensitive sodium channel &agr;-subunit and a splice variant thereof

The present invention is drawn to a novel DNA construct comprising an expression cassette having a constitutive promoter which functions in plant cells operably linked to a maize alcohol dehydrogenase intron, a DNA sequence of a gene encoding a Cry 1Ab protein, and a terminator functional in plants and optionally further comprising a second cassette including a promoter which functions in plants operably linked to a maize alcohol dehydrogenase intron, a DNA sequence of a gene encoding for phosphinothricin acetyl transferase, and a terminator functional in plants wherein the two cassettes are transcribed in the same direction. Also provided are transgenic plants, particularly maize plants, having such a construct stably incorporated into their genomes.

Nucleic acid construct comprising bacillus thuringiensis cry1Ab gene

Disclosed is a stabilized gene for transforming a host plant cell said gene comprising a gene exogenous to the plant cell and at least one stabilizing DNA segment in a 3'- or 5'-flanking region to said exogenous gene. Additionally, the invention relates to vectors comprising at least one stabilizing DNA segment in a 3'- or 5'-flanking region to the exogenous gene and methods for transforming plant cells. These stabilizing DNA segments include MAR, SAR, LCR, or LAR, HR and other repetitive elements.

Genetic stabilizing elements

Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and a

The present invention is directed to promoter fragments isolated from maize and particularly to a 4.7 kbp upstream promoter region designated ZRP2 of a ZRP2 genomic DNA clone, specific fragments thereof designated ZRP2(2.0) and ZRF2(1.0) and functional equivalents thereto. The promoter has particular utility in driving root preferential expression of heterologous genes that impart increased agronomic, horticultural and/or pesticidal characteristics to a given plant. This invention is also directed to DNA molecules including said promoters and transformed plant tissue including a DNA molecule comprising a promoter of the invention operably linked to a heterologous gene or genes and the seeds thereof.

Root preferential promoter

Novel processes for introducing DNA into plant material utilizing non-pulsed electric current, and plant cell lines, differentiated plant tissues and plants produced by said processes.

Electrotransformation process

Growing community of inventors

Palo Alto, CA, United States of America

Paul Shartzer Dietrich