Astrazeneca Ab

Paul Schofield

Andrew Stocker

Paul Michael Murray

Michael Butters

Jeremy Stephen Parker

A process for preparing a compound of formula (I) where Rand Rare as defined in the specification; and Ris hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R, Rand Rare as defined in relation to formula (I), and Ris nitrogen-protecting group, and removing the group R&#x2014;, and thereafter if desired or necessary, removing any protecting group Rto obtain the corresponding carboxylic acid. Novel intermediates and the use of the products in the preparation of pharmaceutical compounds is also described and claimed. 

Process and intermediates for the preparation of the thienopyrrole derivatives

Novel Process and Intermediates. A process for preparing a compound of formula (I) where Rand Rare as defined in the specification; and Ris hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where Rand Rand Rare as defined in relation to formula (I), and Ris nitrogen protecting group, and removing the group R, and thereafter if desired, removing any protecting group R. Novel intermediates and the use of these in the formation of pharmaceutical compounds is also described and claimed 

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Macclesfield, United Kingdom

Paul Schofield