The Governing Council of the University of Toronto

Interface Biologics, Inc.

Sunnybrook Health Sciences Centre

University Health Network

University of Ottawa

Fielding Chemicals Limited

Sunnybrok Health Sciences Centre

Paul Santerre

Sanjoy Mullick

Weilun Chang

Cari Marisa Whyne

Jeffrey Allan Fialkov

Richard Witmeyer

Robert M Pilliar

Eran Regev

Roseita Esfand

Takeshi Matsuura

Kyle Giovanni Battiston

Meilin Yang

Roberto Martin Narbaitz

Hassam Mahmud

Fakhir Baig

Eli Sone

Michael Floros

Soror Sharifpoor

Yi Fang

Wey Liang Leong

Vu Anh Pham

Liang Wey Leong

An adhesive device for biomedical applications is provided comprising a support and one or more water insoluble compounds of structure 1 wherein B is an oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW<10,000 g/mol, Linker L is a urethane, urea bond, or amide bond; Linker L' is a urethane or urea bond, A is a chain extender of Mw≤3000 g/mol comprising substituted or unsubstituted alkyl, cycloalkyl and/or aromatic groups, W is a terminal adhesive benzene-1,2-diol derivative or a terminal adhesive benzene-1,2,3-triol derivative, m is 0 or 1; and n is 0, 1, 2, 3 or 4 or a cross-linked polymer formed from said compounds. The compound(s) have a Tg lower than 25° C.

Adhesive device for biomedical applications and methods of use thereof

Polar hydrophobic ionic materials and, in particular, polar hydrophobic ionic polyurethanes having a minimum ratio of hydrophobic and anionic components to the remainder of the polymer components are provided that exhibit reduced IgG Fab exposure.

Biomaterial with reduced inflammatory response

A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a):(b+c) is between about 1:&#x2265;21 and about 1:30, the soft tissue filler has a porosity of &#x3e;75%; and a compressive moduli of between about 1 kPa and about 50 kPa.

Soft tissue filler

The present disclosure discloses a bone stabilization device (also referred to as a bone tape), which includes a composite flexible construct including a rigidifiable biocompatible sheet structure having first and second opposed surfaces. A biocompatible cement is located on the first surface. In use the composite flexible construct is applied to a bone with the cement contacted directly to the bone. The cement is made of a material that, once adhered to the bone, is curable to mechanically and/or ionically bond to the sheet structure and to chemically bond to the bone to achieve a permanent bond. The bone tape allows simultaneous alignment and stabilization of multiple articulated fragments for successful 3D reconstruction of shattered bones. Initial flexibility and translucency provided by the bone tape can facilitate the temporary stabilization and alignment adjustment of multiple fragments, prior to permanent rigid bonding.

Bone stabilization device and method of production

The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.

Methods and compositions for the delivery of biologically active agents

The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.

Surface modifying macromolecules with high degradation temperatures and uses thereof

The present invention relates to membranes useful in the separation of water from a solution containing volatile organic compounds and water. The membranes may be used in dehydrating an organic/water mixture to purify an organic when an organic is of interest or, alternatively, producing pure water from an organic/water mixture when clean water is of interest. The membranes include a hydrophilic base polymer, an optional pore-forming polymer and a surface modifying macromolecule (SMM) which imparts surface hydrophobicity to the membrane.

Membrane composition and method of preparation

Growing community of inventors

Whitby, Canada

Paul Santerre