Mycogen Corporation

Dow Global Technolgoies LLC

Paul S Zorner

Steven L Evans

Jerry D Caulder

R Hugh Crowley

Robert A Haygood

Steven D Savage

John M Harvey

Jerald S Feitelson

Leo Kim

Ian A Tomlinson

Joseph Francis Krebs

Yasuko Tsujino

Keith Jones

Osamu Kamioka

Jerry Caulder

The subject invention relates to a low cost method of producing peptides, including antimicrobial peptides (AMPs), by using microbes. The subject methods enable greatly improved yields of the peptide/AMP as compared to those heretofore known in the art. The subject methods also surprisingly enable the use ofto produce AMPs and other peptides. There are several components of the subject invention, which can be used alone or in combination. The subject invention provides for the production of peptides/AMPs in concatemeric precursors. The subject invention also provides novel methods of assembling monomers into multimers, and of cleaving the multimers to yield active monomers. The subject invention also relates to the use of these multimers fused to carrier peptides to produce fusion proteins. Preferably, both the multimers and the fusion proteins (multimers with the carrier polypeptides) lack charge balancing. It has been surprisingly determined that it is not necessary to offset the positive charges of multiple copies of AMPs in multimeric constructs. Thus, the subject invention enables the use of a wider range of multimers and carrier peptides.

Low-cost production of peptides

The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.

Fatty acid based compositions for the control of established plant

Fatty acid based compositions and methods for the control of plant

Described and claimed are methods and compositions for the control of unwanted vegetation. According to the subject invention, a fatty acid or mixture of fatty acids can be combined with one or more chemical herbicides to achieve synergistic control of a broad range of plants.

Process and composition for controlling weeds

Process and composition for controlling weeds comprising a C.sub.7 -C.sub.2

Methods and compositions for the control of nematodes are disclosed. Specifically, fatty acid ester compounds have been found to advantageously control nematodes at concentrations which are non-phytotoxic. The fatty acid ester compounds can be used in conjunction with other nematicidal agents such as free fatty acids, fatty acid salts, avermectins, ivermectin, and milbemycin.

Materials and methods for controlling nematodes

Growing community of inventors

La Costa, CA, United States of America

Paul S Zorner