Hoechst Marion Roussel

Other

Sanofi

Aventis Pharmaceuticals Inc.

Merrell Pharmaceuticals, Inc.

Automated Industrial Technologies, Inc.

Paul S Wright

Steven J Busch

Roger A Parker

Mark T Yates

Kim S Chen

Norton P Peet

Alan J Bitonti

Michael L Edwards

David R Borcherding

Jennifer A Dumont

Haifeng Eishingdrelo

Mark J Vaal

Jidong Cai

Paul Weissensee

Francesco Gerald Salituro

Jeffrey Paul Whitten

Ian A McDonald

Esa T Jarvi

Gary Sill

James E Matt

Wayne R Barr

Kelly Mc Gaughey

Rory Westlund

James E Matt, Jr

Ian A Mcdonald

A flexible chain diverter system acts as a moveable diverter 'swing-arm' capable of dispensing groups of bottles into the array of entrance gates for loading onto a shipping pallet. The flexible chain has a variable axial length. As a result of the ability to change in axial length, the diverter described herein can remain taut at the shortest distance gates and can stretch to reach gates at the maximum range of reach. This allows for the path length of travel to be optimized for any gate.

Flexible chain diverter redirection assembly

Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.

Identifying molecules modulating protein-protein interactions using protease activated reporters

Methods and assays for identifying a compound that modulates a protein-protein interaction between a first and a second protein. The methods and assays require a protease that is attached to the second protein and a split and rearranged reporter activating protein that is attached to the first protein, wherein the reporter activating protein comprises a cleavage site for the protease that is interposed between two portions of the reporter activating protein and wherein the two portions of the reporter activating protein are in a rearranged order.

Methods and assays for identifying compounds that modulate protein-protein interactions

The present invention is directed to acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4 -diaminocyclohexyl)-purines of the formula where Z is selected from the group consisting of &#x2014;S(O)&#x2014;, and &#x2014;C(O)&#x2014;.

Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents

A device for separating individual containers from a group of multiple containers and delivering the separated individual container for further processing is shown. The device relies in part on gravity for the movement of the containers.

Vial card slitting apparatus

The present invention is directed to acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines of the formulawhere Z is selected from the group consisting of &#x2014;S(O)&#x2014;, and &#x2014;C(O)&#x2014;.

The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;

Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant

The present invention provides compounds of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Y is thio, oxy or a methylene group; Z is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;

Substituted phenols and thiophenols useful as antioxidant agents

The present invention relates to novel indole derivatives useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, especially estrogen-dependent neoplasms such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing a neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.

Indole derivatives useful to treat estrogen-related neoplasms and

Methods useful for inhibiting VCAM-1 and for treating chronic inflammatory conditions in a patient in need thereof are disclosed comprising administering to the patient effective amounts of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group;

Method of inhibiting vascular cell adhesion molecule-1 and treating

This invention relates to compounds of the formula ##STR1## wherein R.sub.1 and R.sub.6 are each independently C.sub.1 -C.sub.6 alkyl;

Growing community of inventors

Cincinnati, OH, United States of America

Paul S Wright