Alza Corporation

Sequus Pharmaceuticals, Inc.

Aerogen, Inc.

Paul S Uster

Samuel Zalipsky

Francis J Martin

Theresa M Allen

George Z Zhu

Michael Albert Klimowicz

Joseph A Maxwell

Markus Flierl

James L Slater

Richard James Stevens

Kristen M Hjortsvang

Adam A Zetter

Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.

Therapeutic liposome composition and method of preparation

A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized radiosensitizer. In one embodiment, the radiosensitizer is dipalmitoyl-5-iodo-2&prime;-deoxyuridine. A method for preparing the liposome composition including the lipid-derivatized radiosensitizer is also disclosed.

Liposome composition and method for administration of a radiosensitizer

A nebulizing device having two or more nebulizing elements. The nebulizing device may be used to deliver two or more fluids to the patient or may be used for enhanced fluid flow of a single fluid. The nebulizing elements are preferably vibrating elements with holes therein through which the fluid is expelled when the vibrating elements are vibrated.

Methods and devices for nebulizing fluids

A method for loading a therapeutic compound having a cis diol moiety into pre-formed liposomes is described. The method includes adding to a suspension of liposomes (i) the compound to be loaded into the liposomes and (ii) a boronic acid compound, thereby achieving accumulation of the compound within the liposomes.

Liposome loading method using a boronic acid compound

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Tracy, CA, United States of America

Paul S Uster