Other

Baxter International Inc.

Vascular Solutions, Inc.

Medivas, LLC

Quantumcor, Inc

Paul S Teirstein

Yem Chin

Paul Scopton

William L Gould

William B Atkinson

Robert F Carmichael, Jr

Osama Amine

Cary K Hata

David Aaron Schwartz

Hosheng Tu

Henry Nita

Kenneth W Carpenter

Wallace Neil Hauck

Thomas H Witzel

John A Osth

Scott Evans

Jagdish C Dhuwalia

Istvan Szinai

Provided are devices and methods for catheter and guidewire management in a surgical setting. In one implementation, the device includes a housing having a curved bottom surface for accommodating the shape of a patient's leg. A retaining member is included, which can retain one or more guidewires, catheters, or the like. In another embodiment, the housing may include a number of vertical supports between which are mounted at least one retaining member housing. The retaining member housing may in turn house a retaining member, suitable for receiving and retaining one or more elongated devices such as catheters or guidewires. The retaining member may have a suitable size, shape, and level of flexibility to allow a catheter or guidewire to be placed therein and held with a desired level of force until such a time as a user desires to remove the catheter or guidewire.

Guidewire and catheter management device

A device for loading a guide wire into the open end of a tubular instrument, such as a catheter. The device can be a block of material having a groove in its surface. The ends of the guide wire and the tubular instrument are placed into the groove and moved toward each other. When the ends meet, the groove guides the guide wire into the open end of the tubular instrument. The groove, or at least a portion of the groove, can have a cross-sectional contour that closely matches the outside radius of the tubular instrument. The groove can have a substantially vertical wall and a substantially non-vertical wall. A variety of attachment mechanisms may be provided for attaching the device to a towel draping a patient. A retaining member is disposed on the surface of the device for retaining a guide wire or tubular instrument against movement.

Guide wire loading method and apparatus with towel attachment mechanism and retaining member

A device for loading a guide wire into the open end of a tubular instrument, such as a catheter. The device can be a block of material having a groove in its surface. The ends of the guide wire and the tubular instrument are placed into the groove and moved toward each other. When the ends meet, the groove guides the guide wire into the open end of the tubular instrument. The groove, or at least a portion of the groove, can have a cross-sectional contour that closely matches the outside radius of the tubular instrument. The groove can have a substantially vertical wall and a substantially non-vertical wall. A variety of attachment mechanisms may be provided for attaching the device to a towel draping a patient.

Guide wire loading method and apparatus with towel attachment mechanism

A device for loading a guide wire into the open end of a tubular instrument such as a catheter. The device can be a block of material having a groove in its surface. The ends of the guide wire and the tubular instrument are placed into the groove and moved toward each other. When the ends meet, the groove guides the guide wire into the open end of the tubular instrument. The groove, or at least a portion of the groove, can have a cross-sectional contour that closely matches the outside radius of the tubular instrument. The groove can have one portion with a shallower depth than the other portion, with the guide wire run in the shallower portion and the tubular instrument in the deeper portion. The guide wire and the tubular instrument can be angled above the device, with just their ends moving along the groove.

Guide wire loading method and apparatus

A catheter for use with a radioactive source within the catheter to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the blood vessel. The catheter has a guidewire channel formed near its distal end to facilitate use of the catheter as a rapid exchange catheter, allowing insertion of the catheter over a guidewire also used in performance of an angioplasty procedure. The catheter also has a radiation lumen with a sealed end to retain the radioactive source within the catheter. The radiation lumen is sufficiently longer than the guidewire channel to extend into a non-sterile field, keeping the radiation source segregated from the blood, allowing the use of a non-sterile radiation source. The catheter can also be provided with a centering balloon or a set of centering wire loops to center the radioactive source radially within the blood vessel.

Irradiation catheter and method of use

The present invention provides in vivo methods for detection of vulnerable plaque in a subject in need thereof. In the invention method the subject is administered a diagnostic amount of a biologically compatible detectable lipid-avid agent, the detectable lipid-avid agent is allowed to penetrate arterial walls and attach to any lipid accumulations of oxidized LDL-cholesterol in arterial walls in the wall of an artery; unbound detectable lipid-avid agent is allowed to clear from the body by natural processes, and the presence of the detectable lipid-avid agent attached to the lipid accumulation in the wall of the artery is detected. Detection of bound lipid-avid agent indicates the presence of a vulnerable plaque and predicts a heightened risk of lethal heart attack or thrombus. The detectable lipid-avid agent is selected for its ability to penetrate arterial walls and bind with oxidized LDL-cholesterol in the lipid accumulation in a vulnerable plaque. Alternatively, macrophage-avid agents, for example a lipid-avid agent attached to a macrophage-specific antibody, can be used in the invention methods. The invention further includes methods for in vitro assays for detecting vulnerable plaque and a porcine animal model of vulnerable plaque useful for testing treatment modalities.

Animal model for detection of vulnerable plaques

A catheter system and methods for repairing a valvular annulus or an annular organ structure of a patient comprising sandwiching and compressing the annulus and applying heat sufficient to shrink or tighten tissue surrounding the annulus defect.

Catheter system for repairing a mitral valve annulus

A radiation delivery system having an expandable radiation source made of a pliable material. The source body is made of a material such as a foam or sponge, or a fibrous material such as the soft bristles of a pipe cleaner. The spongy or fibrous material is made radioactive by the implantation of a radioactive isotope. The radioactive isotope can be located throughout the pliable source material, or concentrated in a desired region, such as the surface or near-surface region. This compressible radioactive source material, when constrained by a constraining housing or a catheter, has a very low profile. However, when the constraining housing or catheter is withdrawn, the expandable source material expands and fills the surrounding space, such as a blood vessel lumen. In this way, the radioactivity, impregnated in the expandable source material, is brought into direct contact with the vessel wall.

Irradiation catheter with expandable source

A method and apparatus for injecting radiographic dye during angiography. A deformable holding chamber is interposed between a contrast dye bottle and a syringe manifold. A one-way valve and an integral disconnect/flow-stop are connected between the bottle and the holding chamber. A vent is provided in the holding chamber, which can include a second one-way valve. Squeezing and releasing the deformable chamber fills the chamber from the bottle. The holding chamber contains a floating baffle which acts as a shut off valve by plugging the chamber outlet if the chamber becomes empty. The syringe is used to withdraw dye from the holding chamber. If dye remains in the bottle after performance of the procedure, the disconnect/flow-stop fitting can be disconnected, and the dye can be saved.

Method and apparatus for uninterrupted delivery of radiographic dye

A catheter for use with a radioactive source within the catheter to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the blood vessel. The catheter has a guidewire channel formed near its distal end to facilitate use of the catheter as a rapid exchange catheter, allowing insertion of the catheter over a guidewire also used in performance of an angioplasty procedure. The catheter can also have a guidewire channel formed near its proximal end to provide an O-ring sealing surface and to facilitate free guidewire movement. The catheter also has a closed end to retain the radioactive source within the catheter. The catheter can also be provided with a centering balloon or a set of centering wire loops to center the radioactive source radially within the blood vessel.

A method and apparatus for injecting radiographic dye during angiography are provided. A deformable holding chamber is interposed between a contrast dye bottle and a syringe manifold. A one-way valve and an integral disconnect/flow-stop are connected between the bottle and the holding chamber. A vent is provided in the holding chamber, with a second one-way valve. Squeezing and releasing the deformable chamber fills the chamber from the bottle. The holding chamber contains a floating baffle which acts as a shut off valve by plugging the chamber outlet if the chamber becomes empty. The syringe is used to withdraw dye from the holding chamber. If dye remains in the bottle after performance of the procedure, the disconnect/flow-stop fitting can be disconnected, and the dye can be saved.

A method and apparatus for blocking a body passageway by inserting an expandable frame into the passageway and expanding the frame with an expandable balloon to partially embed the frame in the walls of the passageway. The frame can carry a separate sealing membrane, or the balloon can function as the sealing membrane. The sealing membrane, the frame or the balloon can also carry a clot promoting substance. The balloon can be removed along with the inflation tube after the expansion procedure, if it is not serving as the sealing membrane, or the balloon can be detached from the inflation tube and left in place, either as a sealing membrane or simply to lock the frame in place. The frame can be maintained in its expanded state by being plastically deformed during the expansion step, or the frame can be maintained in its expanded state by having the balloon locked in the expanded state and left in place.

Growing community of inventors

La Jolla, CA, United States of America

Paul S Teirstein