Boehringer Ingelheim Pharmaceuticals, Inc.

Paul S Riska

Pier Francesco Cirillo

Neil Moss

Abdelhakim Hammach

Victor Marc Kamhi

Christopher Pargellis

John R Regan

Alan David Swinamer

Zhulin Tan

Brian Andrew Walter

Roger Dinallo

Disclosed are compounds of formula(I): wherein R, R, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Fluorinated di-aryl urea compounds

Disclosed are compounds of formula (I):wherein R, R, W and X of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar ,Ar ,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

Aromatic heterocyclic compounds as antiinflammatory agents

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Danbury, CT, United States of America

Paul S Riska