Astrazeneca Ab

Paul Robert Fleming

Michael Barry Gravestock

Fei Zhou

Neil James Hales

Folkert Reck

Daniel Robert Carcanague

Brian A Sherer

Sheila Irene Hauck

Gregory Steven Basarab

Kenneth Gregory Hull

George Byron Mullen

Oluyinka Morenike Green

Pamela Hill

Haihong Ni

Brian Dangel

Marc Michel Girardot

Greg Basarab

Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. 

Antibacterial piperdine derivatives

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein &#x2014;N-HET is, for example, (Ic) or (If) wherein R1 is (1-4C)alkyl; wherein Rand Rare independently hydrogen or fluoro; wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein &#x2014;N-HET is, for example, (Ic) or (If) wherein R1 is, for example, halogen or a (1&#x2013;4C)alkyl group which is substituted by one substituent selected from, for example, hydroxy, (1&#x2013;4C)alkoxy, amino, cyano or azido; Q is selected from, for example, Q1 wherein Rand Rare independently hydrogen or fluoro;T is selected from a range of groups, for example, wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

Chemical compounds

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Paul Robert Fleming