Xenon Pharmaceuticals Inc.

Genentech, Inc.

Paul Robert Bichler

Christoph Martin Dehnhardt

Shaoyi Sun

Brian Salvatore Safina

Sultan Chowdhury

Alla Yurevna Zenova

Thilo Focken

Michael Edward Grimwood

Ivan William Hemeon

Michael Scott Wilson

Qi Jia

Jean-Christophe Andrez

Philippe Bergeron

Abid Hasan

Wei Gong

Shannon Marie Decker

Tao Sheng

Daniel P Sutherlin

Daniel Fred Ortwine

Gregory N Beatch

Jean-Jacques Alexandre Cadieux

Jun M Li

Zhiguo Liu

Jiuxiang Zhu

Andrew D White

Chien-An Chen

Matthew David Tandy

Jun Li

The present disclosure provides solid state forms of a selective potassium channel modulator and pharmaceutical compositions comprising the solid state crystalline forms and pharmaceutically acceptable excipients, and methods for preparing and using the solid state forms and the pharmaceutical compositions thereof.

Solid state crystalline forms of a selective potassium channel modulator

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted triazolopyridines and methods of use thereof

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Burnaby, Canada

Paul Robert Bichler