Kallyope, Inc.

Paul Richards

Shuwen He

Iyassu Sebhat

Ann Weber

Brett Lauring

Lisa Krug

Nancy Thornberry

This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists or partial agonists.

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New York, NY, United States of America

Paul Richards