Corixa Corporation

Vertex Pharmaceuticals, Inc.

Immunex Corporation

Other

Sanofi

Sterling Winthrop Inc.

Paul R Sleath

Raymond L Houghton

Roy A Black

Steven G Reed

Michael J Lodes

Shirley R Kronheim

Patricia Dianne McNeill

David H Persing

Jeffrey N Fitzner

Davin C Dillon

Darrick Carter

Thomas R Tice

Thomas S Vedvick

Gary R Fanger

Marc W Retter

Tongtong Wang

Nancy Ann Hosken

Michael D Kalos

Robert A Henderson

Jay K Staas

Craig H Day

Chaitanya S Bangur

Syamal Raychaudhuri

Patrick McGowan

Yoshihiro Watanabe

Heather Secrist

Margarita Durham

Andria McNabb

Jeffrey C Johnson

Mary J Homer

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Compositions comprising a lung tumor antigen

There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1&#x3b2; and for a substrate comprising:R&#x2014;Asp&#x2014;R&#x2014;Rwherein Rand Rare independently any D or L isomer amino acid, Ris Ala or Gly, and wherein the specific protease cleavage site is between Asp and R. Inhibitor compounds, compositions and methods for inhibiting Interleukin 1&#x3b2; protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp.

Interleukin 1&#x3b2; protease and interleukin 1&#x3b2; protease inhibitors

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

Compositions and methods for the therapy and diagnosis of breast cancer

Compounds and methods for the diagnosis and treatment of infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

Compounds and methods for the diagnosis and treatment of B. microti infection

Compounds and methods for the diagnosis and treatment of HSV infection are provided. The compounds comprise polypeptides that contain at least one antigenic portion of an HSV polypeptide and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits are also provided comprising such polypeptides and/or DNA sequences and a suitable detection reagent for the detection of HSV infection in patients and in biological samples.

Compositions and methods for the diagnosis and treatment of herpes simplex virus infection

Compounds and methods for the diagnosis and treatment of infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a antigen, DNA sequences encoding such polypeptides, and fusion proteins comprising such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences, fusion proteins or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences, fusion proteins or antigenic epitopes and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

A composition for inducing or potentiating an immune response, preferably a CTL, T helper cell, or neutralizing antibody response in a subject, comprising an antigen and/or a non-antigen bioactive agent capable of inducing or potentiating such an immune response encapsulated in a polymeric composition, wherein the polymeric composition comprises a blend of (a) a polymer present in an amount sufficient to provide structural integrity to the polymeric composition, and (b) a rapidly biodegradable component, a rapidly dissolving component, a rapidly swelling component, or a component that causes osmotic rupture of the encapsulated polymeric composition is disclosed. Single polymer compositions for achieving such an immune response are also disclosed. Methods for inducing or potentiating a CTL, T helper cell or neutralizing antibody response using the above-identified compositions are disclosed.

Rapid release encapsulated bioactive agents for inducing or potentiating an immune response and methods of using thereof

Compounds and methods for the diagnosis and treatment of,infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a,antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of,infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1.beta. and for a substrate comprising:

Interleukin 1.beta. protease and interleukin 1.beta. protease inhibitors

Compounds and methods are disclosed that are useful in inhibiting the TNF-.alpha. converting enzyme (TACE) responsible for cleavage of TNF-.alpha. precursor to provide biologically active TNF-.alpha.. The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as, hydroxamates, thiols, phosphoryls and carboxyls.

Inhibitors of TNF-.alpha. secretion

Growing community of inventors

Seattle, WA, United States of America

Paul R Sleath