The Liposome Company, Inc.

Transave Limited

Elan Pharmaceuticalstechnologies, Inc.

Paul R Meers

Andrew S Janoff

Shaukat Ali

Donna J Cabral-Lilly

Charles Pak

Tong Shangguan

Patrick L Ahl

J Craig Franklin

Ravi K Erukulla

Ravi Erukulla

This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agents in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to cells.

Encapsulation of bioactive complexes in liposomes

A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome may also include a stabilizing moiety interposed between the linking and targeting moieties, and covalently bound to both. Alternatively, the stabilizing and targeting moieties may be covalently bound to separate linking moieties, the linking moieties being electrostatically bound to the lipid bilayer.

Modular targeted liposomal delivery system

Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.

Peptide-lipid conjugates, liposomes and lipsomal drug delivery

This invention provides liposomes containing one or more N-acylated phosphatidylethanolamines, such liposomes being useful for localizing the delivery of bioactive agents to cells.

N-acyl phosphatidylethanolamine-mediated liposomal drug delivery

Liposomal peptide-lipid conjugates and delivery using same

Peptide-lipid conjugates

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Princeton Junction, NJ, United States of America

Paul R Meers