3m Innovative Properties Company

Solventum Intellectual Properties Company

Paul R Klaiber

Yizhong Wang

Joel D Oxman

Tiffany T Ton

Jie Jerry Liu

Afshin Falsafi

Carola A Carrera Vidal

Jennifer J Post

Kenton D Budd

Richard Paul Rusin

Jason W Bjork

George W Griesgraber

Sumita Basu Mitra

Matthew S Stay

Paul J Homnick

Masayuki Nakamura

Jana Ninkovic

Mark B Agre

Melinda B Gustafson

Randilynn B Christensen

Bruce R Broyles

Naimul Karim

Reinhold Hecht

Yi He

Jie Yang

Richard B Ross

Brian A Shukla

Katie Fraass Wlaschin

Bhaskar V Velamakanni

Matthew R D Smith

Hannah C Cohen

Roxanne A Boehmer

Petra L Kohler Riedi

Mahmut Aksit

Bradley D Craig

Bill H Dodge

Jodi L Connell

Henry C Gydesen

Kevin T Reddy

Joanne A Fitch

Ingo R Haeberlein

Jennifer Post

A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition for application to a tooth structure.

Hardenable dental compositions comprising basic core material encapsulated in an inorganic shell and dispensing devices therewith

A method of applying a two-part dental sealant is described comprising providing a syringe device () comprising a cartridge () including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle () comprising a static mixer and an outlet at one end of the cartridge and a plunger () at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

Two-part dental sealant, method of applying with a syringe device, and kit

An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patients tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.5 wt-% to 4.8 wt-% of a water-soluble cationic N-containing polymer; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.

Aqueous oral care fluoride treatment compositions, and methods

A dispenser () for liquids includes a reservoir () defining a volume (V) for housing a liquid (); a delivery tube () with a first end () attached to the reservoir, and a second end () distal from the reservoir, the delivery tube including a passage () in fluid communication with the volume of the reservoir and extending away from the reservoir; an applicator element () including an applicator tip () and a base () attached to the second end of the delivery tube, the applicator tip having a plurality of fingers () extending away from the base to a distal end of the applicator element distal from the delivery tube; and a removable seal (), wherein removal of the removable seal creates an opening in the passage at a location upstream of the applicator tip and a fluid distribution channel between the fingers.

Dispenser with applicator tip

An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.

An oral composition and a method of delivering an oral composition to a dental structure are described. The oral composition can include a solvent; an acidic copolymer having acidic acrylate monomeric units, acidic methacrylate monomeric units, or a combination thereof; a neutral copolymer having neutral acrylate monomeric units, neutral methacrylate monomeric units, or a combination thereof; and optionally an active agent. The acidic and neutral copolymers can be dissolved in the oral composition and the oral composition can form a film on a surface when contacted with an aqueous solution.

Oral compositions, dental structures and methods of delivering oral compositions

Substituted saccharide compounds, dental compositions comprising substituted saccharide compounds, and methods of using dental compositions are described. In one embodiment, the substituted saccharide amide compound comprises a hydrophobic group and at least one free-radically polymerizable group with the proviso that the hydrophobic group is not bonded to the ethylenically unsaturated carbon atom of the free-radically polymerizable group. The hydrophobic group is typically bonded to a nitrogen atom of a saccharide amine residue or a carbonyl moiety of saccharide amide residue.

Substituted saccharide compounds and dental compositions

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Mahtomedi, MN, United States of America

Paul R Klaiber