Bristol-myers Squibb Compnay

Bristol-myers Company

Takeda Pharmaceutical Company Limited

Paul R Brodfuehrer

Zhiyuan Zhang

Kun M Shih

Steven P Brundidge

Donald G Walker

Patrick R Smith

J Gregory Reid

Chet Sapino, Jr

Joydeep Kant

Vittorio Farina

Xinhua Qian

Daniel A Benigni

Maxwell M Reeve

Philip B Kisanga

Thomas R Sattelberg

Thomas R Sattleberg, Sr

Paul K Isbester

A process is provided for preparing chiral diol sulfones of the structurewhere Ris preferablywhere Ris preferably aryl such as phenyl, and Ris preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.

Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors

The present invention provides a process for the expoxidation of a protected 3-methylene-(trans)-1,2,-hydroxymethylcyclopropane with cyclohexanone and potassium peroxymonosulfate and subsequent rearrangement to provide the corresponding cyclobutanone.

Method for epoxidation of 3-methylenecyclopropanes

This invention relates to a method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids from 3-hydroxymethyl-3-cephem-4-carboxylic acids in an aqueous medium for a practical, large-scale production. Moreover, the invention provides an ideal intermediate for the process.

Preparation and use of

A novel process utilizing adenosine deaminase to selectively produce .beta.-(D)-2',3'-dideoxyinosine in high yields from an .alpha.,.beta.-anomeric mixture. .beta.-(D)-2',3'-Dideoxyinosine so produced is useful as an antiviral and antibiotic agent.

Dideoxyinosine by enzymatic deamination of dideoxyadenosine

Process for preparing cephalosporin intermediates

Stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl and Nu and Nu.sup..sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the .DELTA..sup.2 isomer; processes for, and intermediates in, the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.

Cephalosporin intermediates

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Syracuse, NY, United States of America

Paul R Brodfuehrer