Novartis Ag

Commonwealth Scientific and Industrial Research Organisation

Paul Pasic

Peter Chabrecek

Richard Alexander Evans

Graham M Johnson

Helmut Werner Thissen

Laurence Meagher

Peter Kambouris

Yongxing Qiu

Lynn Cook Winterton

John Martin Lally

Hans Jorge Griesser

Hans Jörg Griesser

Hans J&ouml;rg Griesser

The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerization initiators and a plurality of surface binding groups. Pendant polymers may be grafted from at least some of the polymerization initiators.

Polymeric coatings and methods for forming them

The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerization initiators and a plurality of surface binding groups; and pendant polymers grafted from at least some of the polymerization initiators.

The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bnd to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherences to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.

Process for surface modifying substrates and modified substrates resulting therefrom

Coating process

Growing community of inventors

Melbourne, Australia

Paul Pasic