Abbott Laboratories Corporation

Other

Paul P Ehrlich

Yat Sun Or

Nan-Horng Lin

Michael J Dart

James P Sullivan

Mark W Holladay

Hao Bai

Keith Brian Ryther

James T Wasicak

John K Lynch

Stephen P Arneric

Jerome F Daanen

Michael D Meyer

Michael R Michaelides

Maureen Ann McLaughlin

Robert W Schoenleber

John W Kebabian

James R Campbell

Chi-Nung Hsaio

Jeffrey W Ralston

3-Pyridyl enantiomers and their use as analgesics

The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

Compounds having the formula are .alpha..sub.1 adrenoreceptor antagonists. Processes for making these compounds, synthetic intermediates employed in these processes and a method for inhibiting .alpha..sub.1 adrenoreceptors and treating benign prostatic hyperplasia (also called benign prostatic hypertrophy or BPH) and other urological diseases such as BOO (bladder outlet obstruction), neurogenic bladder and gynecological syndromes such as dysmenorrhea are disclosed.

3-phenylpyrrolidine alpha-1 adrenergic compounds

For attaching a decorative skirt about the peripheral edge of a banquet table, a one-use disposable plastic hanger advantageously coated during a production run on a single side over side and top length portions in surrounding relation about a pivotal tab with adhesive, such that in use adhesive on the noted length portions are adhesively attached to the table edge and the tab, after a 270 degree pivotal transverse, is in an outwardly facing relation from the table edge and thus in position to complete an adhesive attachment to the decorative skirt.

Table skirt-attaching hanger

A process for preparing a chiral tetracyclic compound of formula: ##STR1## wherein R is hydrogen or a C.sub.1 -C.sub.6 -alkyl group and Z is oxygen, sulfur or --CH.dbd.CH--, the compounds having uses as dopamine agonists. The process involves reacting a chiral starting material and subsequent chiral intermediates in a series of chirality-preserving synthetic reactions.

Process for preparing chiral tetracyclic dopaminergic compounds

A method of attaching a decorative skirt about a banquet tablecloth using spring clips with Velcro patches in which initially the spring clips in spaced apart relation are engaged to extend radially from the tablecloth but are then pivoted, as allowed by the flexibility of the cloth, into a vertical plane in which the Velcro patches thereon face outwardly of the table and are readily attached to a cooperating Velcro strip on the decorative skirt.

Table skirt-attaching method and attaching clip

Novel tetracyclic spirobenzazepine compounds of the formula ##STR1## or a pharmaceutically-acceptable salt, amide or ester thereof, which are dopamine D-1 receptor antagonists useful for treating dopamine-related neurological and psychological disorders, cognitive impairment, attention deficit disorders and addictive behavior disorders.

Tetracyclic spirobenzazepine dopamine antagonists

For attaching a decorative skirt from an edge of a banquet table to mask the legs or otherwise enhance the appearance thereof, the addition to clips which are clipped to the table edge of a first velcro strip which engages a second velcro strip on the skirt, the first velcro strip also preventing, because the clips are attached to it, the inadvertent misplacement of the clips when the skirt is removed for cleaning or the like.

Table skirt-attaching method

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Libertyville, IL, United States of America

Paul P Ehrlich