Other

Merck Frosst Canada, Inc.

Merck Frosst Canada & Co.

Merck Canada Inc.

Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Paul O'Shea

Richard D Tillyer

Xin Wang

Cheng Yi Chen

Sophie-Dorothee Clas

Chad Dalton

Francis Gosselin

Jeffrey C Moore

Paul N Devine

Feng Xu

Robert D Larsen

Gregory Hughes

Ian W Davies

Dalian Zhao

Lushi Tan

John Y Chung

Kevin Matthew Maloney

Christophe Mellon

Weirong Chen

Louis-Charles Campeau

Greg Hughes

Edward J J Grabowski

Bruce S Foster

Philippe Dagneau

Danny Gauvreau

Anthony On-Ping King

Melina Girardin-Rondeau

Stephane Ouellet

The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.

Process for the preparation of an orexin receptor antagonist

This invention describes an amidation process whereby amino acids of the Formulae IIA or IIB can be activated and treated with an amine in the presence of a base to yield amides of the Formula (I), without loss of optical purity. 

Amidation process for the preparation of cathepsin K inhibitors

This invention describes a reductive amination process whereby perfluorinated ketones or ketals are combined with &#x3b1;-aminoesters under basic conditions to form metal carboxylates. Diastereoselective reductions of the metal carboxylates enable access to two diastereomers, depending on the reducing conditions.

Diastereoselective reductive amination process

This invention describes the reaction of an alpha fluoroalkyl ketone with a bis(trialkylsilyl)amide to give a stable N-trialkylsilyl imine. Treatment of the N-trialkylsilyl imine with an alcohol leads to solvolysis of the trialkylsilyl group and yields a stable mixture of an aminal and an imine in high yield. Catalytic reduction of this mixture, or of the individual components, in the presence of a chiral catalyst leads to a fluoroalkyl amine with high enantioselectivity and high yield.

Synthesis of alpha fluoroalkyl amines

Synthesis of ketosulfone esters

2-lithio-5-halopyridine is formed as a predominant component of a reaction mixture by reacting BuLi with 2,5-dihalopyridine in a non-coordinating solvent.

Process for making 2, 5-substituted pyridine

This invention encompasses a novel process for synthesizing compounds represented by formula A:

Synthesis of methylthiophenyl hydroxyketones

This invention encompasses a novel process for synthesizing the compound represented by formula I:

Synthesis of 4-&lsqb;(5-substituted phenyl)-3-substituted-1H-pyrazol-1-yl&rsqb;benzenesulfonamide

This invention encompasses a novel process for synthesizing the compound represented by formula I: ##STR1## These compounds are useful as non-steroidal anti-inflammatory agents.

Synthesis of 4-[5-substituted or unsubstituted

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Westmount, Canada

Paul O'Shea