Eastman-kodak Company

Johnson & Johnson Clinical Diagnostics, Inc.

Paul Nicholas Schnipelsky

Raymond Francis Jakubowicz

John Bruce Findlay

Charles C Hinckley

William Harold Donish

Jeffrey A Wellman

Leonard J Seaberg

A cuvette and a method of use prevent nucleic acid amplified by PCR technology from being released to the atmosphere, while still proceeding to a detection step to determine whether or not the nucleic acid is present. Detection reagents are either pre-incorporated into compartments in the cuvette or added after amplification. In the latter case, a check valve prevents amplified nucleic acid from being released. Transfer of liquids between compartments is achieved via the use of flexible compartment walls and an external pressure source, or via pistons that are part of the cuvette and operate on the compartments as a piston within a piston chamber.

Containment cuvette for PCR and method of use

A cuvette and a method of use which prevent nucleic acid amplified by PCR technology from being released to the atmosphere, while still proceeding to a detection step to determine whether or not the nucleic acid is present. Detection reagents are either pre-incorporated into compartments in the cuvette or added after amplification. In the latter case, a check valve prevents amplified nucleic acid from being released. Transfer of liquids between compartments is achieved via the use of flexible compartment walls and an external pressure source, or via pistons that are part of the cuvette and operate on the compartments as a piston within a piston chamber.

In an analyzer of the kind in which a reflectometer contacts a test element during scanning of the element, means are provided for moving test elements to and from the reflectometer in a manner avoiding significant contact wear of the reflectometer.

Analyzer featuring a contacting reflectometer

A method and apparatus are disclosed for performing chemical analysis on selected fluids. The fluids are dispensed onto a test element which is transported to an analysis device where a radiometer or potentiometer is provided for measuring a characteristic of the test element resulting from the fluid deposited thereon.

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Rochester, NY, United States of America

Paul Nicholas Schnipelsky