Sterix Limited

Paul Michael Wood

Barry Victor Lloyd Potter

Atul Purohit

Lok Wai Lawrence Woo

Michael John Reed

Christian Bubert

Oliver Brook Sutcliffe

Aurélien Putey

Christian Burbert

There is provided a compound of formula I  wherein t is 1 or 2wherein R'is a unsubstituted or substituted phenyl group;wherein each of Rto Ris independently selected from &#x2014;H, NO, halo, &#x2014;O&#x2014;(C-C)haloalkyl, (C-C)haloalkyl, (C-C)alkyl, &#x2014;CN, &#x2014;OH, &#x2014;OPh, &#x2014;OBn, -Ph, &#x2014;OSONRR, &#x2014;SOR, &#x2014;SONRR, &#x2014;O&#x2014;(C-C)alkyl, &#x2014;(C&#x2550;O)NRRand &#x2014;CO(O)R;

Compound

The present invention relates to steroid sulphatase and/or aromatase inhibitors of Formula III or Formula IV, wherein A is selected from H, OH, halogen and hydrocarbyl; D, E and F are each independently of each other an optional linker group; P, Q and R are independently of each other a ring system, wherein Rand Rare independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl or optionally contain one or more hetero atoms or groups, and which can be used in medicine.

Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity

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Slough, United Kingdom

Paul Michael Wood