New York University

Paul Michael Levine

Kent Kirshenbaum

Timothy W Craven

Justin M Holub

Michael J Garabedian

Novel peptoid oligomers are disclosed that have a formula represented by the following formula Ia or Ib: The peptoid oligomers are prepared as modulators of androgen receptor (AR), and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals, including humans, associated with unwanted or aberrant AR activity. The present peptoid oligomers are particularly valuable for the treatment of subjects with cancer.

Multivalent peptoid oligomers, pharmaceutical compositions and methods of using same

Novel hybrid polymers are disclosed that have a structure represented by the following formula I: wherein Abiotic oligomer, Polypeptide, X, Y, and Rare as described herein. The methods to prepare the hybrid polymers via novel oxazolidinyl compounds are also described.

Hybrid polymers, pharmaceutical compositions and methods of synthesizing the same

Novel methods to prepare novel polymers are disclosed. Oxazolidinyl compounds according to formula IV: are also disclosed as intermediate compounds that can be reacted with an acid to form a polymer of formula I.

Polymers, pharmaceutical compositions and methods of synthesizing the same

Novel hybrid polymers are disclosed that have a structure represented by the following wherein Abiotic oligomer, Polypeptide, X, Y, and Rare as described herein. The methods to prepare the hybrid polymers via novel oxazolidinyl compounds are also described.

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New York, NY, United States of America

Paul Michael Levine