Ortho Diagnostic Systems Inc.

Immunomedics, Inc.

Paul M Kaplan

Raymond P Zolton

John V Padvelskis

Rudolph P Reckel

Joanne L Harris

Ralph Wellerson, Jr

Sally M Shaw

Method and test kit for detecting Clq-containing complexes in human serum containing native serum Cl. The method uses a monoclonal antibody which selectively reacts with human Clq in the presence of native human serum Cl. Preparation of hybridomas generating such antibodies is also disclosed. The method is applicable to detection of autoimmune diseases and AIDS.

Method for detecting immune complexes in serum

Methods for producing from human plasma or serum, human gamma globulin free of hepatitis-B-virus infectivity and products resulting therefrom. Specifically provided are ion exchange resin/buffer systems capable of effectively removing the virus.

Methods for preparation of highly purified, gamma globulins free of

Methods for producing from human serum, human gamma globulin essentially free of HB.sub.s Ag and products resulting therefrom. Specifically provided are ion exchange resin/buffer systems capable of effectively removing HB.sub.s Ag thought to be closely correlated with viral hepatitis type B infectivity. Additional steps can include ultrafiltration to increase reduction of any virus not removed in the column passage as well as the addition of anti-HB.sub.g to substantially eliminate all infectivity.

Methods for preparation of HB.sub.s Ag free gamma globulins

Growing community of inventors

Sergeantsville, NJ, United States of America

Paul M Kaplan