Sanford Burnham Prebys Medical Discovery Institute

University of Central Florida Research Foundation Inc

Duke University

Sanford-Burnham Medical Research Institute

Paul M Hershberger

Patrick R Maloney

Anthony B Pinkerton

Satyamaheshwar Peddibhotla

Layton H Smith

Danielle McAnally

Michael P Hedrick

Otto Phanstiel

Holly Moots

Marc G Caron

Lawrence S Barak

Lawrence Barak

Danielle Mcanally

Various embodiments relate to compounds and methods useful for preventing or treating a cancer in a subject. The method may include administering to a subject a composition according to any of the embodiments described herein in an amount effective to inhibit metastatic activity or tumor growth in the subject.

Non-polyamine based polyamine transport inhibitors and their use in the treatment of human cancers

Provided herein are agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Apelin receptor agonists and methods of use thereof

Provided herein are agonists of the apelin receptor of Formula (I): for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.

Substituted pyrazolo[1,5-a]pyrimidines as apelin receptor agonists

Anthranilic acid derivatives and their use in the treatment of human cancers

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Small molecule agonists of neurotensin receptor 1

Growing community of inventors

La Jolla, CA, United States of America

Paul M Hershberger