University of Rochester

Temple University

University of Nebraska

University of Kansas

Paul M Dunman

Wayne Everett Childers

Patrick D Olson

Wayne Childers

Daniel Patrick Flaherty

Damian J Krysan

Rachel Wozniak

Catlyn E Blanchard

The present invention features an antibacterial composition comprising 1) a composition A comprising polymyxin B and trimethoprim; and 2) an antibiotic agent selected from the group consisting of rifampicin, rifabutin, rifapentine, rifaximin, pefloxacin mesylate, sparfloxacin, sarafloxacin HCl, tobramycin, lomefloxacin, besifloxacin, danofloxacin mesylate, enrofloxacin, nadifloxacin and clinafloxacin, a topical pharmaceutical thereof, and a method of treating bacterial infections using mixtures of 1 and 2.

Pharmaceutical composition containing polymyxin B/trimethoprim based therapeutics

The present invention features a composition comprising zinc pyrithione and silver sulfiadizine, a formulation thereof and a method of treating microbial infection using the composition.

Prevention and treatment for microbial infections

The present invention features a composition comprising mupirocin and neomycin, a formulation thereof and a method of treating microbial infection using the composition.

Antimicrobial compositions comprising mupirocin and neomycin

Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.

Small molecule efflux pump inhibitors

Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.

Synergistic compositions for treating microbial infections

Provided herein are compositions and methods for treating or preventing infection.

Methods and compositions for treating infection

Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

Small molecule RNase inhibitors and methods of use

Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.

Growing community of inventors

Pittsford, NY, United States of America

Paul M Dunman