Rafael Pharmaceuticals, Inc.

The State University of New York

Cornerstone Pharmaceuticals, Inc.

Shorr, Robert

Rodriguez, Robert

Boteju, Lakmal

Marecek, James

Bingham, Paul

Kwok, Thomas

Paul M Bingham

Zuzana Zachar

Robert G Shorr

Robert J Rodriguez

Thomas Kwok

Lakmal Boteju

James Marecek

Tom Kwok

Robert Rodriguez

Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations comprising such analogs or derivatives and pharmaceutically-acceptable carriers therefor, are useful for the treatment, prevention, imaging, and/or diagnosis of medical disorders.

Pharmaceutical compounds

Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive to lipoic acid derivatives.

Lipoic acid derivatives

This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications.

Lipoic acid derivatives and their use in treatment of disease

Growing community of inventors

Centereach, NY, United States of America

Paul M Bingham