Eli Lilly and Company

Miami University

Paul Luther Skatrud

Robert Brown Peery

Jo Ann Hoskins

Patti J Treadway

Thomas D Ingolia

Stephen W Queener

Michele Louise Young Bellido

Chyun-Yeh Earnest Wu

Maarten A De Waard

Alan C Andrade

Pamela Kay Rockey

Q May Wang

Paul R Rosteck, Jr

Anne H Dantzig

Stanley Richard Jaskunas, Jr

Franklin H Norris

JoAnn Hoskins

Paul Robert Rosteck, Jr

Michele Louise Bellido

Suellen M Samson

William Ernest Alborn, Jr

Larry C Blaszczak

Otis W Godfrey

Scott C Mauldin

Steven Kovacevic

James R Miller

Mohammad Sadegh Zia-Ebrahimi

Cathleen Alice Cantwell

Jnanendra K Bhattacharjee

Michael Scott VanNieuwenhze

Kevin R Kaster

Roland L Hodges

Richard C Garrad

Matthew Barry Tobin

Jerry L Chapman, Jr

Barbara J Wiegel

Lucinda G Carr

Serhat Unal

Susan Jane Thornewell

A process is described for preparing a substrate for the transglycosylase enzymes of bacterial cell wall biosynthesis. The chemical synthesis makes available a sustainable and substantially pure source of supply of lipid II, including analogs thereof, that may be used in the identification of new therapeutic agents capable of disrupting steps in bacterial cell wall biosynthesis.

Process for preparing lipid II

The invention provides isolated nucleic acid compounds encoding the 454 gene of . Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene HI0454

The invention provides isolated nucleic acid compounds encoding HI1648 of Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence HI1648

The invention provides isolated nucleic acid compounds encoding FtsZ of Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence FtsZ

The present invention provides DNA compounds that encode ACV synthetase activity of,. The compounds can be used to construct recombinant DNA expression vectors for a wide variety of host cells, including,, Penicillium, Cephalosporium, and Aspergillus.

Recombinant DNA compounds that encode ACV synthetase activity of Cephalosporium acremonium

The invention provides isolated nucleic acid compounds encoding enzyme mraY of,Also provided are vectors and transformed host cells for expressing the encoded enzyme, and a method for identifying compounds that inhibit said enzyme.

Streptococcus pneumoniae gene sequence mraY

The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of,Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of,atrD are also provided. The invention further provides assays which utilize these transformed host cells.

Multiple drug resistance gene atrD of Aspergillus nidulans

The present invention provides DNA compounds that encode the expandase/hydroxylase enzyme of,. The compounds can be used to construct recombinant DNA expression vectors for a variety of host cells, including,Penicillium, and Cephalosporium.

Recombinant DNA expression vectors and DNA compounds that encode deacetoxycephalosporin C synthetase and deacetylcephalosporin C synthetase

The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of,Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

Muri protein from Streptococcus pneumoniae

The invention provides isolated nucleic acid compounds encoding a novel MTG of Staphylococcus aureus. Also provided are vectors and transformed heterologous host cells for expressing the MTG and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the MTG.

Monofunctional glycosyltransferase of Staphylococcus aureus

The invention provides isolated nucleic acid compounds encoding FtsH of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Strepococcus pneumoniae gene sequence FtsH

The invention provides isolated nucleic acid compounds encoding HI1146 of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence HI1146

The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrC are also provided. The invention further provides assays which utilize these transformed host cells.

Multiple drug resistance gene atrc of Aspergillus nidulans

The invention provides isolated nucleic acid compounds encoding FtsY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.

Streptococcus pneumoniae gene sequence FtsY

The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.

Growing community of inventors

Greenwood, IN, United States of America

Paul Luther Skatrud