Dow Agrosciences LLC

Dow Agroscienceas LLC

Paul Lewer

Paul Richard Graupner

Jeffrey Ryan Gilbert

Clive Waldron

Christine Janet Martin

Lesley S Burns

William A Vousden

Raymond C Yao

Laura Lee Karr

Gary D Crouse

John F Daeuble, Sr

Donald R Hahn

Barrie Wilkinson

Thomas V Worden

Dennis W Norton

Nadaraj Palaniappan

Jesse L Balcer

Barnie Wilkinson

Jeffrey R Gilbert

Peter B Anzeveno

Paul R Graupner

M Paige Oliver

Lesley S Sheehan

This disclosure concerns methods for producing a spinosyn producing host cell that comprises modifying a nucleic acid molecule encoding for spinactin by introducing, mutating, deleting, replacing or inactivating a nucleic acid sequence encoding one or more activities of a polypeptide encoded by the nucleic acid molecule. Methods for producing a modifiedorganism or strain are also disclosed.

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The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning into produce the spinosyns, and methods of controlling insects using the spinosyns.

Spinosyn-producing polyketide synthases

Macrolide compounds produced by synthetic modification of factors produced by NRRL 30141 have insecticidal and acaricidal activity and are useful intermediates for preparing additional insecticidal and acaricidal compounds

Synthetic derivatives of 21-butenyl and related spinosyns

Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.

Pesticidal macrolides

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Indianapolis, IN, United States of America

Paul Lewer