Warner-lambert Company

Paul Leroy Creger

Alan Robert Saltiel

Charles Larry Bisgaier

Sherrie Rae Tafuri

Milton L Hoefle

Ann Holmes

Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.

Carboxyalkylethers, formulations, and treatment of vascular diseases

Novel 4-amino substituted phenoxyalkyl carboxylic acid, ester, and alcohol derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.

4-amino substituted phenoxyalkyl carboxylic acid, ester, and alcohol

Novel 4-oxy substituted phenoxyalkyl carboxylic acid, ester and alcohol derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.

4-oxy-substituted phenoxyalkyl carboxylic acid, ester, and alcohol

An improved process for the preparation of mono-, di-, or trisubstituted acetic acids including 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid by a novel synthesis is described where a carboxylic acid is converted to a soluble metalated magnesium or zinc carboxylate containing a ligand and subsequent alkylation of this intermediate in the presence of an alkali amide to afford the desired product in two steps.

Process for mono-, di-, trisubstituted acetic acids

Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2- dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.

Novel

Novel N-(substituted-phenyl)-5-(substituted-2,5-dimethylphenoxy)-2,2-dimethylpen tan amides which are useful in preventing the intestinal absorption of cholesterol and also increasing high-density lipoprotein (HDL) cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.

Growing community of inventors

Ann Arbor, MI, United States of America

Paul Leroy Creger