Wisconsin Alumni Research Foundation

Other

Yeda Research and Develpment & Co. Ltd

Paul L Kaufman

Benjamin Geiger

Hector Floyd Deluca

Alexander Bershadsky

Galina D Kutuzova

Teresa Borras

B'Ann True Gabelt

Xuyang Liu

Hector F Deluca

The present invention relates to compounds and methods for reducing intraocular pressure and treating ocular hypertension in a subject.

Vitamin D compounds and methods for reducing ocular hypertension (OHT)

A method for reducing intraocular pressure and increasing outflow facility from an eye of a subject having glaucoma includes the step of providing in the trabecular meshwork of the eye an amount of caldesmon effective to reduce intraocular pressure and increase outflow facility.

Method for treating glaucoma

A method for increasing outflow facility and reducing intraocular pressure from an eye of a subject having glaucoma includes the step of administering to the eye an amount of an ADP ribosyltransferase protein effective to reduce intraocular pressure and increase outflow facility.

Methods for the treatment of glaucoma are provided by the present invention. The compounds described cause a perturbation of the actin cytoskeleton in the trabecular meshwork or the modulation of its interactions with the underlying membrane. Perturbation of the cytoskeleton and the associated adhesions reduces the resistance of the trabecular meshwork to fluid flow and thereby reduces intraocular pressure.

Cytoskeletal active agents for glaucoma therapy

Methods for the treatment of glaucoma are described. The compounds described cause a perturbation of cell adhesions in the trabecular meshwork, mainly via disruption of the associated cytoskeletal structures or the modulation of their interactions with the underlying membrane. Perturbation of these adhesions reduces the resistance of the trabecular meshwork to fluid flow and thereby reduces intraocular pressure.

A centrifugal switch employing the fluent and electrical conducting properties of mercury to open or close an electrical circuit. The mercury is confined within an enclosed chamber and is used as an electrical conducting connector between spaced contact members. Rotating and nonrotating conditions of the switch are relied upon for electrical conduction through the mercury for switch operation.

Growing community of inventors

Madison, WI, United States of America

Paul L Kaufman