The University of Birmingham

Beecham Group Plc

Rhodia Limited

Paul L Coe

Richard T Walker

Albert S Jones

Claude Mercier

Tony Waring

Stewart A Noble

Compounds containing a primary amino group are converted into compounds containing a fluorine atom in place of the amino group by reaction of the amino compound with hydrogen fluoride and a nitrosating reagent under the influence of ultrasound or microwaves.

Process for the preparation of fluoro compounds from the corresponding amines

1'-Deoxy-5-ethyl-4'-thio-.beta.-uridine as a compound including its physiologically functional derivatives, pharmaceutical compositions containing it and methods of treating herpes virus infections are described.

Antiviral pyrimidine nucleosides and methods for using same

Pyrimidine 4'-thionucleosides of the formula I ##STR1## wherein Y is hydroxy or amino, and X is chloro, bromo, iodo, trifluoromethyl, C.sub.2-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 haloalkenyl or C.sub.2-6 alkynyl and physiologically functional derivatives thereof. These compounds have utility as anti-vital agents.

Antiviral pyrimidine nucleosides

The compound of formula (I): ##STR1## wherein X is CFCl; and C.sub.1-6 alkanoyl esters and/or phosphate esters thereof, is active against herpes viruses.

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Birmingham, United Kingdom

Paul L Coe