Other

Chiron Corporation

Chiron Viagene, Inc.

Gensia Pharmaceuticals, Inc.

Paul K Laikind

Douglas J Jolly

James G Respess

Harry E Gruber

Harry E Guber

Jack R Barber

Sunil D Chada

Daniel C St Louis

John F Warner

Stephen M W Chang

Kevin M Mullane

Stephen M Chang

Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.

Chimeric gene constructs

Method for inhibiting human tumor cells

Replication defective viral vectors for infecting human cells

Recombinant retroviruses

Method for making reflection defective retroviral vectors for infecting

Method for destroying a diseased human cell

Methods of preventing tissue damage associated with decreased blood flow in a human by administering AICA riboside or a prodrug thereof in an amount which provides a blood plasma concentration of between 1 .mu.g/ml and 20 .mu.g/ml of AICA riboside for a time sufficient to reduce the risk of said tissue damage in said human. Methods of preventing an adverse clinical outcome, such as an adverse cardiovascular and/or cerebrovascular event, in a patient at risk for such outcome by administering AICA riboside or a prodrug thereof in an amount which provides a blood plasma concentration of between 1 .mu.g/ml and 20 .mu.g/ml of AICA riboside for a time sufficient to reduce the risk for said patient.

Methods of preventing tissue damage associated with decreased blood flow

Recombinant retroviruses expressing a protein that converts a pro-drug

Growing community of inventors

San Diego, CA, United States of America

Paul K Laikind