Merck Sharp + Dohme Corp.

Novartis Ag

Merck + Co., Inc.

Paul Joseph Oakley

Martin Richard Teall

Timothy Harrison

Duncan Edward Shaw

Brian John Williams

Stephen Paul Collingwood

Alan John Nadin

Nichola Smith

Kevin Dinnell

Ian Churcher

Sonia Kerrad

Catherine Howsham

Lee Edwards

Peter Hunt

Gurdip Bhalay

Emma Budd

Graham Charles Bloomfield

Thomas Anthony Hunt

Andrew Dunstan

Peter Gedeck

Andrew Pate Owens

Susannah Williams

Jose Luis Castro Pineiro

Susannah William

Robin Alec Fairhurst

Stephen Robert Fletcher

Jeremy Peter Scott

Stephen John Lewis

Frank Burkamp

Edward Giles Mciver

Emily Stanley

Richard Alexander Jelley

Antony John Davies

Karel Marie Joseph Brands

Rebecca Butler

Karl Richard Gibson

Maria Ines Rodriguez Perez

Abdul Quddus

Graham David Checksfield

Jonathan David Wrigley

Dirk Beher

A compound of Formula I in free or salt or solvate form, where R, R, R, R, R, R, R, R, R, Rand Rhave the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Treating diseases mediated by blockade of the epithelial sodium channel with pyrazine-2-carboxamide derivatives

A compound of formula (I), or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M, M, L, L, W, W, X, X, Y, Y, A, Rand Rare as defined herein for the for treatment of conditions treatable by the blockade of an epithelial sodium channel, particularly conditions benefiting from mucosal hydration. 

Organic compounds 75074

Tetrahydroindole derivatives of formula (I): are disclosed. These compounds modulate the activity of gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease. 

Tetrahydroindole derivatives for treatment of alzheimer's disease

Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel

Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of &#x3b3;-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma-secretase

Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma secretase

Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.

Cyclohexyl sulphones as gamma-secretase inhibitors

Novel sulphones of formula I are disclosed:  The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Cyclohexyl sulphones

A novel process for preparing cyclohexanone derivatives of formula (I) is described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

Synthesis of cyclohexanone derivatives

Compounds of formula I: wherein Arand Arare optionally substituted aryl or heteroaryl, L is a bond, &#x2550;CH&#x2014; or &#x2014;(CHR)&#x2014;, and X is SCN, SR, S(O)R, (CRR)SOR, SON(R), SONHCOR, SONHN(R), OSON(R, OS(O)N(R), OSONHCOR, COR, NHCOR, NHCOR, NHCON(R), NHSORor NHSON(R), inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.

Cyclohexyl sulphone derivatives as gamma-secretase inhibitors

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Growing community of inventors

South Benfleet, United Kingdom

Paul Joseph Oakley