Zoetis Services LLC

United States of America, as Represented by the Secretary of Agriculture

Zoetis LLC

Pfizer Corporation

Zoetis Belgium S.a

Pfizer Products Inc.

Zoetis P LLC

Pah USA 15 LLC

Paul Joseph Dominowski

John Morgan Hardham

Richard Lee Krebs

Sharath K Rai

Duncan Mwangi

Dennis L Foss

Suman Mahan

Risini Dhammika Weeratna

James Richard Thompson

Cedo Martin Bagi

Tedd Alan Childers

Mary Kathryn Olsen

Robert John Yancey, Jr

Shaunak Vora

Shucheng Zhang

Sangita Mediratta

Aida Elizabeth Rieder

Luis Leandro Rodriguez

Cyril Gay

Ramasamy M Mannan

Peter William Krug

Ramasamy Mannar Mannan

Lauren Wilmes

Sarah A Salmon

Kaori Mohr

Sandra Ann Marie Lightle

Guillermo Gallo

James Alan Jackson

Jacqueline Gayle Marx

Laia Plaja Dilmé

Oscar Romero Galindo

Alicia Urniza Hostench

Marta Cabana Sumsi

Monica Balasch Sanuy

Vicki Jon Rapp Gabrielson

Harmen Jacob Geerligs

Joseph Michael Bricker

Pamela K Klose

Carla Maria Batista De Freitas

Maria Carolina Ferreira Dos Santos

Pamela Kay Klose

Steven Alan Dunham

Heather Lynn Davis

Mahesh Kumar

Shelly Lynn Shields

Joseph C Frantz

Eric Baima

Mark D Goodyear

Michael John Huether

Jason John Millership

Laurel Mary Sly

Sharon Marie Wappel

Nicole Lynn Hainer

Robert Greg Sorensen

Anita Dorota Jaglarz

Traci K Godbee

Yulia Burakova

Cyril Gerard Gay

Sumsi Marta Cabana

Hostench Alicia Urniza

Sanuy Monica Balasch

Dilme Laia Plaja

Galindo Oscar Romero

Corey Patrick Cook

Martin Cedo Bagi

Robert J Yancy

Robert John Yancey

David George Emslie Smith

Joseph M Bricker

Joseph Claude Frantz

Carla Maria De Freitas

Maria Carolina Dos Santos

William Donachie

Michael Christopher Fontaine

Julie Lydia Fitzpatrick

Laia Plaja Dilme

The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

Vaccine compositions for porcine epidemic diarrhea virus and porcine deltacoronavirus

The invention provides stable coronavirus spike proteins. Immunogenic compositions comprising same and the methods of using these immunogenic compositions are also provided.

Anti-coronavirus vaccines

Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 μg FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.

Foot-and-mouth disease vaccine

The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.

Methods and composition for induction of immune response

Poultry vaccines against infectious bronchitis and Turkey Rhinotracheitis are provided. The vaccines are adjuvanted with oil emulsion containing an immunostimulatory oligonucleotide. The methods of using the vaccines are also provided.

Vaccine against infectious bronchitis

The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

Oil-based adjuvants

This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

Adjuvant compositions

Methods and compositions for induction of immune response

Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 &#x3bc;g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.

Growing community of inventors

Kalamazoo, MI, United States of America

Paul Joseph Dominowski