Arizona State University

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Washington University

Paul Jones

Mark A Hayes

Thomas J Taylor

LaKeta Kemp

Claire Crowther

Aadel Chaudhuri

Michael Keebaugh

Prasun Mahanti

Angela Hirbe

Sarah Staton

Jeffrey Szymanski

Russell Sundby

Stacy Kenyon

Noah Weiss

John Shern

Among the various aspects of the present disclosure is the provision of methods for detecting cancer in Neurofibromatosis Type 1 (NF1) patients.

Liquid biopsy to detect cancer early and sensitively in patients with neurofibromatosis type 1

The present technology relates to improved device and methods of use of insulator-based dielectrophoresis. This device provides a multi-length scale element that provides enhanced resolution and separation. The device provides improved particle streamlines, trapping efficiency, and induces laterally similar environments. Also provided are methods of using the device.

Hyper efficient separations device

The present invention provides devices and methods to separate and concentrate target species. In some embodiments, a punctuated continuous microchannel or parallel processing (array-based) separations are provided, the microchannel having a plurality of sequential, constrictive insulating features to form a plurality of reservoirs including a first, second and third reservoir, and a plurality of constricted passageways including a first constricted passageway that connects the first reservoir to the second reservoir and a second constricted passageway that connects the second reservoir to the third reservoir. A voltage is applied to the microchannel to create different electrical fields and/or different dielectrophoresis (DEP) gradients at each of the plurality of constricted passageways in order to separate species that have differing ratios of electrokinetic mobility to dielectrophoretic mobility.

Punctuated microgradients for improved separations of molecules and particles

The present invention provides for separation of bacterial species and serotypes using electrophoretic methods.

Bacterial identification

Growing community of inventors

Mesa, AZ, United States of America

Paul Jones