Wyeth

Oscient Pharmaceuticals Corporation

Mayo Foundation for Medical Education and Research

Paul John Yaworsky

Kristina Allen

Wei Liu

Anthony Anisowicz

Christopher Todd Brown

Jimin Zhang

Stephane Olland

Zhijian Lu

James R Graham

Emily Sheng-Ming Shen

Veronique Damagnez

Arturo Morales

John Allen Robinson

Bheem M Bhat

Claudia Kappen

Members of the TGF-&#x3b2; superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.

Finger-1 peptide analogs of the TGF-&#x3b2; superfamily

The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.

Reagents and method for modulating Dkk-mediated interactions

The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.

HBM variants that modulate bone mass and lipid levels

The invention provides methods and materials related to the regulation of nucleic acid expression. Specifically, the invention provides midbrain-specific and NS-specific regulatory elements as well as regulatory elements that potentiate nucleic acid expression and regulatory elements that cooperate with other regulatory elements. In addition, the invention provides temporal regulatory elements that regulate nucleic acid expression in a temporal manner. Further, the invention provides nucleic acid constructs that contain these regulatory elements in combination with selected nucleic acid sequences. The invention also provides cells and animals that contain these regulatory elements and constructs as well as methods of providing an animal with a selected nucleic acid sequence that is expressed in a tissue-specific or temporal manner.

Tissue-specific regulatory elements

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Rockland, MA, United States of America

Paul John Yaworsky