Sterling Drug Inc.

The Hilton-davis Chemical Co.

Other

Gilead Sciences, Inc.

Nexstar Pharmaceuticals, Inc.

Antriabio, Inc.

Pr Pharmaceuticals, Inc.

Glead Sciences, Inc.

The Hilton-davis Chemical

Paul J Schmidt

William M Hung

Nathan N Crounse

Clark Evan Davis

Larry M Gold

Nebojsa Janjic

Chandra Vargeese

Danny H Lewis

Kenneth Hinds

Patrick J Jefferies

Michael Willis

Kathleen M Campbell

Damian Pacheco

William Mo-Wei Hung

A joint for furniture uses alternating tabs and slots formed along an edge of first and second furniture panels. The panels are joined together so that tabs in the first panel are disposed in slots in the second panel and tabs in the second panel are disposed in slots in the first panel. This arrangement causes the slots to flex outwardly and the tabs to flex inwardly once assembled and creates residual stress in the assembled joint which stiffens the joint.

Furniture with interwoven tab and slot joint

An improved joint is provided for modular furniture. The joint includes a dovetail shaped tab and a corresponding slot. The tab is held in the slot such that the tab is maintained in an elastically bent position while the item of modular furniture is in an assembled configuration. The tab and slot provides increased stiffness and rigidity to the piece of furniture while allowing the piece of furniture to be assembled without fasteners such as screws or nails.

Modular furniture with stressed dovetail tab joint

An joint is provided for modular furniture. The joint includes a locking tab which is held in a slot such that the tab cannot be moved out of a locking section of the slot without elastically bending the tabbed panel to prevent inadvertent disassembly of the item of furniture. The tab and slot configuration may also provide increased stiffness and rigidity to the piece of furniture while allowing the piece of furniture to be assembled without fasteners such as screws or nails.

Modular furniture with locking tab and slot joint

An improved joint is provided for modular furniture. The joint includes a dowel and slot. The dowel is held in the slot tightly to provide stiffness to the joint. The dowel may include a flanged head which is bent elastically by the slot when the dowel is fully inserted into the slot. The head of the dowel may be maintained in a bent configuration when the joint is in assembled configuration.

Furniture with flexible dovetail dowel and slot joint

A modular shelving unit includes a plurality of shelves supported by supports. Non-linear attachment pins are attached to the top of a lower shelf and received in upper supports which support an upper shelf. The attachment pins are bent so that they are wider than holes in the upper supports; bending the attachment pins elastically and maintaining them elastically bent when the shelving unit is in an assembled state.

Modular stackable shelves

A joint for modular furniture includes a first panel joined to a second panel with a slot and a tab. The slot and tab are formed with complementary faces which are angled to prevent delamination of anisotropic materials such as plywood.

Modular furniture with distributed pressure panel joint

A modular shelving system includes a wall panel with slots and shelf brackets with tabs which attach to the wall panel slots. The tabs have upwardly sloping surfaces which engage sloped surfaces on the back side of the slots. These mating surfaces better retain the tabs into the slots and provide a higher degree of strength in the tab and slot joint. This allows the shelving system to be made with smaller tabs and thinner material than previously possible; providing a more secure and visually appealing shelving system.

Modular shelf system with tab and slot mounting

An article of modular furniture such as a drawer, case, cabinet, or table is provided. The article of furniture uses a first panel with a dovetail tab and a straight tab and a second panel with a dovetail slot and a straight slot. The first panel is flexed in order to insert the dovetail tab and the straight tab into the respective dovetail slot and straight slot and is then un-flexed to complete the assembly.

Modular furniture with stressed panel dovetail joint

A stackable wooden crate that can be assembled and disassembled without tools, and stored flat is provided. The crate may include: two sides with box joint tabs, two sides with matching box joint recesses, a bottom, and a lid. The sides may come together at box joints held together with strap binding that stretches tight when the sides are folded 90 degrees to each other. A modified strap binding on one corner of the box is held tight via a tensioner buckle. The bottom is held captive by the four sides. The lid rests between four tabs that extend upward out of all four sides. When the lid is removed, multiple crates can be stacked, the upper crate held in place by the lower crate's four tabs which interface with recesses on the bottom of the upper crate.

Stackable and collapsible crate

The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.

Site-specific insulin-polymer conjugates

Materials and methods for preparing protein-polymer conjugates

This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound.

Nucleic acid ligand complexes

This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.

Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes

Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.

Growing community of inventors

Sharonville, OH, United States of America

Paul J Schmidt