Pharma Mar, S.a.

Harbor Branch Oceanographic Institution, Inc.

Paul J Scheuer

Dolores Garcia Gravalos

Mark T Hamann

Tatsuo Higa

Toshio Ichiba

Kalahide F, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions.

Cytotoxic and antiviral compound

Kalahide F. of formula I below, may be isolated from a secoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions. ##STR1##

The present invention is directed to two novel compounds isolated from a Pacific sponge, Plakortis (Homosclerophorida, Plakinidae) which are designated herein as epidioxymanadic acids A and B. These two compounds have been obtained by a bioassay-guided (i.e., antibiotic activity) isolation procedure, involving solvent partition and chromatography on Sephadex LH-20, cyano, and C-18 columns, from extracts of sponge. ##STR1##

Epidioxymanadic acids A and B

This invention relates to antitumor cyclohexanone compositions and derivatives thereof, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are cyclohexanone and derivatives thereof which are derived from marine organisms, i.e., the acord worm, Ptychodera sp.

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Honolulu, HI, United States of America

Paul J Scheuer