Merrell Toraude Et Compagnie

Other

Merrell Dow Pharmaceuticals

Paul J Schechter

Eugene L Giroux

Nellikunja J Prakash

John M Orwin

Christian K Hinze

The present invention pertains to the use of 1,4-disubstituted-piperidinyl compounds in the treatment of insomnia. Said compounds have the following general formula: ##STR1## wherein: each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, a C.sub.1-6 alkyl group, halogen, trifluoromethyl, hydroxy, a C.sub.1-6 alkoxy group, or an amino group; n is 2, 3, or 4; and the pharmaceutically acceptable acid addition salts thereof.

Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a

This invention relates to a novel method for treating hypertension, which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S or NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2, or 3.

Use of .alpha.,.alpha.'-dithiobis-(.beta.-arylacrylic acid) derivatives

This invention relates to a novel method for enhancing zinc serum and tissue concentrations which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.

Use of .alpha.,.alpha.'-dithiobis(.beta.-arylacrylic acid) derivatives

This invention relates to a novel method for combatting heavy metal poisoning which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.

This invention relates to a novel method for combatting poisoning resulting from heavy metals which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.

Use of .alpha.-mercapto-.beta.-arylacrylic acid derivatives in heavy

This invention relates to a novel method for the treatment of hypertension which comprises administering a compound of the formula: ##STR1## wherein Z is C.dbd.C, O, S, NH; R is hydrogen, methyl, ethyl, hydroxy, methoxy, ethoxy, chlorine, bromine, fluorine, iodine or trifluoromethyl; and n is 1, 2 or 3.

Method of treating hypertension

Zinc serum and tissue levels are enhanced by therapeutic administration of certain .alpha.-mercapto-.beta.-aryl acrylic acids.

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Strasbourg, France

Paul J Schechter