Ibis Biosciences, Inc.

Neomatrix, LLC

Nse Products, Inc.

Qualigen, Inc.

Paul J Gleason

Rex O Bare

Steven A Hofstadler

Jared James Drader

Jose R Gutierrez

Jeffrey Christopher Smith

Robert D Miller

Timothy John Payne

Kevin B Morton

Jeffrey C Smith

Jared H Nathanson

James C Hannis

Kevin Oberkramer

Ronald K Bergold

Andrew J Scherer

Dale G Kern

Vijay K Mahant

Christopher C Feistel

Glenn D Walker

Kevin S Oberkramer

A device for delivery of TENS current, attachable to a handheld skin treatment device with a mechanical motion source, comprises a housing for mounting on the handheld skin treatment device, with a conductive skin contact head with first and second electrodes for receiving a TENS signal as a voltage established between the electrodes and a connector mounted in or on the housing and configured to interface with the mechanical motion source to receive the motion of the motion source. The device has an energy converter in the housing to convert the motion into electrical current, a power control circuit for receiving the electrical current and converting it into at least one power supply output voltage; and a signal generation circuit connected to the at least one the power supply output voltage for producing as an output a TENS signal for delivery to skin.

TENS attachment for device for cleansing and treating skin

The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.

Systems for bioagent indentification

The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.

Ionization probe assemblies

Systems, computer program products, and methods useful for handling or managing microplates are provided.

Microplate handling systems and related computer program products and methods

Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.

Sample processing units, systems, and related methods

The present invention provides devices, apparatuses, and systems for lifting and mounting of clinical- and research-related equipment. In particular, the present invention provides a lift and mount system for mass spectrometers (e.g., for time of flight (TOF) mass spectrometers (MS)).

Lift and mount apparatus

Disclosed is a disposable closed fluid loop for providing heat and compression to an intraductal fluid aspiration device. A plurality of bladders are configured to receive a pressurized inflation fluid, and to inflate in response thereto. The fluid is further configured to flow adjacent a heat exchanger, thereby receiving thermal energy, which it imparts to the bladders through conduction. Accordingly, the disclosed fluid loop provides heated inflation media to inflate a plurality of bladders to provide heat and compression to an intraductal fluid aspiration patient.

Disposable fluid loop for intraductal fluid aspiration system

Disclosed is a method and apparatus for accomplishing a noninvasive screen for breast disease markers, including breast cancer markers and cytologically abnormal cells. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The removed sample is thereafter assayed for the presence of cytologically abnormal cells and/or one or more breast disease markers. In addition to the diagnostic applications of the disclosed method and apparatus, a therapeutic application is also contemplated wherein intraductal fluids are noninvasively aspirated using compression, heating and suction cycles to remove toxic buildups within the fluid.

Method and apparatus for noninvasive intraductal fluid diagnositc screen

Disclosed is an apparatus for noninvasive intraductal fluid aspiration. Intraductal fluid is noninvasively aspirated using compression, heating and suction cycles. The device is configured to provide a compression force, deliver heat, and apply a vacuum pressure to encourage the aspiration of patient fluid. The device includes an adjustable support and a movable wall for applying compression. Withdrawn fluid may be used either for diagnostic or therapeutic purposes.

Growing community of inventors

Laguna Niguel, CA, United States of America

Paul J Gleason