Defined Diagnostics, LLC

Pdl Biopharma, Inc.

Wellstat Diagnostics, LLC

Paul Hu

Reid W Von Borstel

Xiaofen Huang

Jeffrey Allan Miller

Lana Hoang Do

The disclosure relates generally to methods of detecting and quantifying methotrexate (MTX) in a sample. The methods disclosed herein decrease cross-reactivity and improve sensitivity of the detection.

Compounds and methods for the detection of methotrexate

Disclosed are methods of measuring enzyme activity in a sample. The methods use disulfide-containing detection reagents with an electrochemiluminescent functional group.

Electrochemiluminescence (ECL) detection reagents and related methods for measuring enzyme activity

The present invention relates to conjugates of 5-fluorouracil, 5-fluorouracil immunogens, antibodies that bind 5-FU and/or 5-FU conjugated to another molecule, and assays for detecting, quantitating, and monitoring amounts of 5-fluorouracil in a sample such as in blood plasma.

Assays, antibodies, immunogens and compositions related to 5-FU

The present invention relates to method of detecting activity of a sample. Some methods involve detecting a neo-binding-site created by the activity such as detecting an activity of a protease by detecting a neo-binding-site created by cleavage of a substrate by the protease.

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Frederick, MD, United States of America

Paul Hu