Gilead Sciences, Inc.

Paul Hrvatin

Paul A Roethle

Ryan McFadden

Hong Yang

Randall Halcomb

Manoj C Desai

Hon Chung Hui

John O Link

Michael L Mitchell

Lianhong Xu

Hongtao Liu

Kerim Babaoglu

Hongyan Guo

Randall W Vivian

Kyla Bjornson

Eric Lansdon

Yingmei Qi

James G Taylor

Elizabeth M Bacon

Gediminas J Brizgys

Brandon Heath Brown

Richard Hung Chiu Yu

James D Trenkle

Darin Allen

Jessica Jade Chao

Erwina Rudio

Ryan Mc Fadden

Randall L Halcomb

James Taylor

Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Modulators of toll-like receptors

The present invention provides methods of preparing 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one and related compounds.

Methods of preparing toll-like receptor modulators

The invention provides compounds and salts thereof as d herein. The invention also provides pharmaceutical compositions comprising a compound disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection, treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds disclosed herein.

2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS

Naphthalene acetic acid derivatives against HIV infection

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I). 

Naphth-2-ylacetic acid derivatives to treat AIDS

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South San Francisco, CA, United States of America

Paul Hrvatin