Sequenom, Inc.

Agena Bioscience, Inc.

Paul Heaney

Chao Lin

David Opalsky

Andrzej Maczuszenko

Phillip Bruce, Iii

Charles Griswold

Sheila A Walker

Thomas Becker

Aaron A Hanson

Ralf Wörl

Xian-Wei Yao

Michael C Willis

Aaron Hanson

A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on a surface, such as a microarray, without contacting any of the deposited material. Sample is delivered by contacting the pin tool with the surface; the amount delivered is proportional to the velocity of the pin tool as it contacts the surface or the velocity of the liquid when movement of the pin is halted.

Method and apparatus for delivery of submicroliter volumes onto a substrate

Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.

Methods and devices for performing chemical reactions on a solid support

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Solana Beach, CA, United States of America

Paul Heaney