Lonza Ag

Lonza Inc.

Other

Lonza Guangzhou Pharmaceutical Ltd.

Basel

Lonza Guangzhou Research & Development Center Ltd

Paul Hanselmann

Stefan Hildbrand

Wolfgang Wenger

Ellen Klegraf

Uta Glufke

Michael Bersier

Peter Fankhauser

Dieter Scherer

Barry Jackson

Ulrich Daum

Wilhelm Quittmann

Dominique Michel

Hanspeter Mettler

Stephan Elzner

Anna Kulesza

Alessandro Falchetto

Herbert Vogel

Brigitta Heyl-Frank

Candid Stoffel

Heilam Wong

Yanling Yang

Etienne Sterren

Daniel Shan

Christof Aellig

Martina Eichenberger

Sarah Filliger

Florencio Zaragoza Dörwald

Daniel Friedrich Fischer

Christian Oliver Kappe

Andreas Heyl

Reta Zhu

Lothar Ott

Gökhan Aras

Jieping Wei

Martin Gmur

Bernhard Gutmann

Christopher Hone

Manuel Koeckinger

Martina Dressel

Stefan Elzner

Yanlei Chen

The invention discloses a method for preparation of 1,4-sorbitan by dehydration of D-sorbitol, wherein one equivalent of water is removed and a cyclization occurs, followed by a treatment with ethanol and isopropanol.

Method for preparation of 1,4-sorbitan

The invention discloses a method for preparation of 5-fluoro-2-methyl-3-nitrobenzoic acid and its methyl ester by conversion of 5-fluoro-2-methylbenzoic acid with fuming nitric acid and oleum and subsequent conversion with methanol.

Method for preparation of 5-fluoro-2-methyl-3-nitrobenzoic acid and its methyl ester

The invention discloses a method for preparation of 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine by conversion of 5-nitro-2-propylthiopyrimidine-4,6-diol with phosgene in the presence of DMF.

Method for preparation of chlorinated s-propylthiobarbituric acid

The invention relates to a method for the production of L-carnitine, wherein a &#x3b2;-lactone, which is a 4-(halomethyl)oxetane-2-one, is converted into carnitine with trimethylamine (TMA), wherein the &#x3b2;-lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamine. The invention also relates to a carnitine having a unique impurity profile.

Process for the production of carnitine from &#x3b2;-lactones

Enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates of formula wherein Ris Calkyl, Rand Rare independently hydrogen or fluorine, M is an alkali or alkaline earth metal, and n is 1 or 2, are prepared from enolate salts of the corresponding 4-fluoro-3-oxobutyrates and carbon monoxide. The enolate salts of formula I can be alkylated or acylated to obtain the corresponding enol ethers and esters. The 4-fluoro-3-oxobutyrate starting material can be prepared from 1,1-difluoroethyl methyl ethers by SbF-catalyzed fluoromethane elimination followed by halogen exchange with lithium chloride, reacting the thus obtained fluoroacetyl chloride with ketene and quenching with the appropriate alcohol R&#x2014;OH. 

Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3 oxo-butyrates

The invention relates to a method for the production of L-carnitine, wherein a chiral &#x3b2;-lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X&#x2014;CH&#x2014;CHO, wherein X is selected from Cl, Br, I and trimethylamine, in the presence of a chiral catalyst.

Process for the production of carnitine by cycloaddition

Process for removing hydrogen cyanide from ethanedinitrile by contacting hydrogen cyanide-containing ethanedinitrile with an organic reagent under formation of a covalent bond.

Process for removing hydrogen cyanide from ethanedinitrile

The present invention relates to a process for the selective preparation of acetaldehyde, characterized in that acrolein and one or more ammonium salts dissolved in water are reacted continuously under high pressures and at temperatures of 300-400&#xb0; C.

Process for the selective preparation of acetaldehyde from acrolein and one or more ammonium salts dissolved in water

A method for the production of 6,6,6-trihalo-3,5-dioxohexanic acid esters of formula (I): in addition to the enols thereof and &#x3c;I&#x3e;E&#x3c;/I&#x3e; and &#x3c;I&#x3e;Z&#x3c;/I&#x3e; isomers, wherein X independently represents fluorine, chlorine or bromine and Rrepresents alkyl, cycloalkyl, aryl or aralkyl. A method for the production of enol ethers of formula (Ib): and the enols thereof (E and Z isomers) wherein X and Rhave the above-mentioned meanings.

Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters

The invention relates to &#x3b2;-alanine amides of general formula (I), wherein: Rrepresents hydrogen or Calkyl that is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, optionally substituted aryl or heteroaryl, and; Rrepresents hydrogen or Rand R, together, form a group of formula &#x2014;(CH)&#x2014;, wherein n is 3 or 4. Said &#x3b2;-alanine amides are produced without using an amino protective group by reacting the corresponding amine with a cyanoacetic ester in order to form an acetamide and by effecting a subsequent catalytic hydrogenation. The method is suited, in particular, for producing carcinine (&#x3b2;-alanyl-histamine, R?1=imidazol-4-ylmethyl, R=H), a naturally occurring pseudo dipeptide, which is used as an active ingredient having an antioxidative effect in medicaments and cosmetics.

Method for preparing &#x3b2;-alaninamides

A method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters of formula (I): in addition to the enols thereof and &#x3c;I&#x3e;E&#x3c;/I&#x3e; and &#x3c;I&#x3e;Z&#x3c;/I&#x3e; isomers, wherein X independently represents fluorine, chlorine or bromine and Rrepresents alkyl, cycloalkyl, aryl or aralkyl. A method for the production of enol ethers of formula (Ib): and the enols thereof (E and Z isomers) wherein X and Rhave the above-mentioned meanings.

A method for the production of 6,6,6-trihalo-3,5-dioxhexanoic acid esters of formula (I): in addition to the enols thereof and &#x3c;I&#x3e;E&#x3c;/I&#x3e; and &#x3c;I&#x3e;Z&#x3c;/I&#x3e; isomers, wherein X independently represents fluorine, chlorine or bromine and Rrepresents alkyl, cycloalkyl, aryl or aralkyl. A method for the production of enol ethers of formula (Ib): and the enols thereof (E and Z isomers) wherein X and Rhave the above-mentioned meanings.

Described are prepolymer compositions on the basis of novolak cyanates of the general formulawherein n is a number from 0 to 20 and the radicals R are identical or different and represent hydrogen or methyl. The compositions contain: 30 to 90 parts by weight of a prepolymer from novolak cyanates (I) wherein R=hydrogen (Ia) and 10 to 70 parts by weight of novolak cyanates (I) wherein R=methyl (Ib), and optionally highly disperse silicon dioxides and/or particulate or fibrous fillers. The inventive compositions are solid at normal temperature and can be ground to flowable powders. They have excellent stability when stored and are easy to process and especially suitable for use as the resin component in base materials for printed circuits on resin-bound abrasive products.

Novolak cyanate-based prepolymer compositions

Compounds of the general Formula:in which

Acetoacetylated N-phenyl-p-phenylenediamines

The method for producing N-alkoxy-N-alkylamides of general formula (I):wherein Rrepresents C-alkyl, cyclo-C-alkyl, cyclo-C-alkenyl, C-alkenyl, aryl, aryl-C-alkyl, heteroaryl, heteroaryl-C-alkyl or heterocyclyl; and Rrepresents Calkyl. In the process, an ester of general formula (II): RCOOR, wherein Rhas the above-mentioned meaning, and Rrepresents C-alkyl, 4-nitrophenyl, 2,4-dinitrophenyl, succinimido or benzotriazole-1-yl, is reacted with hydroxylamine, a hydroxylamine derivative or with a hydroxylammonium salt, and the reaction product is alkylated in the presence of a phase transfer catalyst.

Method for producing N-alkoxy-N-alkylamides

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Brig-Glis, Switzerland

Paul Hanselmann